甲泼尼龙冲击递减疗法联合小剂量免疫球蛋白治疗重症过敏性紫癜的效果观察与护理

Effect observation and nursing of methylprednisolone pulse decreasing therapy combined with small dose of immunoglobulins in treatment of severe anaphylactoid purpura

目的：探讨甲泼尼龙冲击递减疗法联合小剂量免疫球蛋白治疗重症过敏性紫癜的效果，同时施以临床路径护理，以巩固临床效果。方法：选取2012年1月～2014年1月112例过敏性紫癜患儿为研究对象，随机等分为观察组与对照组，对照组给予甲泼尼龙冲击递减疗法，观察组在此基础上加用小剂量免疫球蛋白，比较两组患儿相关指标变化及临床疗效情况。结果：观察组治疗效果明显优于对照组，两组比较差异有统计学意义（P〈0．05）；观察组在皮肤紫癜消退时间、消化道症状消退时间、关节症状消退时间、肾损害好转时间、医疗费用明显低于对照组，在满意度上明显高于对照组，两组比较差异有统计学意义（P〈0．05）。结论：甲泼尼龙冲击递减疗法联合小剂量免疫球蛋白治疗重症过敏性紫癜，疗效显著，加强护理可改善临床症状，缩短住院时间，提高满意度。

Objective ： To explore the effect of methylprednisolone pulse decreasing therapy combined with small dose of immunoglobulins in treatment of severe anaphylactoid purpura, and simultaneously implement nursing of clinical pathway, in order to consolidate clinical effeet. Methods： Selected 112 anaphylactoid purpura children patients from January 2012 to January 2014 as research objects, and randomly divided them into observation group and control group. The control group was given with methylprednisolone pulse decreasing therapy, while the observation group was added with the use of small dose of immunoglobulins on this basis. Compared the change of relevant indicators and clinical efficacy of children patients in the two groups. Results ： The therapeutic effect of the observation group was significantly better than that of the control group, and the difference between the two groups was of statistical significance （P 〈 0.05 ） ;the fading time of skin purpura, fading time of digestive tract symptoms, fading time of joint symptoms, time for renal damage improvement and medical expense of the observation group were significantly lower than those of the control group, the satisfaction was significantly higher than that of the control group, and the differences between the two groups were of statistical significance （ P 〈 0.05 ）. Conclusion ： Methylprednisolone pulse decreasing therapy combined with small dose of immunoglobulins has outstanding efficacy in treatment of severe anaphylactoid purpura, and enhancing nursing can improve clinical symptoms, shorten hospital stay and improve satisfaction.