加用茶多酚片辅助治疗慢性肾小球肾炎的效果观察

Clinical effect observation of added tea polyphenol tablet in the adjuvant treatment of chronic glomerulonephritis

目的探讨加用茶多酚片辅助治疗慢性肾小球肾炎的临床效果。方法选取2012年12月—2014年11月笔者所在医院收治的原发性慢性肾小球肾炎患者70例,随机分为治疗组和对照组,各35例,对照组采用临床基础治疗,治疗组在此基础上,加用茶多酚片,观察比较两组疗效及相应指标。结果治疗组痊愈21例,好转13例,有效率97.1%;对照组痊愈9例,好转14例,有效率65.7%。治疗组有效率显著优于对照组患者,差异具有非常显著性意义(P<0.01)。治疗组和对照组治疗后24 h尿蛋白、Scr、BUN等与治疗前比较,差异具有统计学意义(P<0.05);两组患者各项指标治疗后比较,治疗组优于对照组,差异具有统计学意义(P<0.05),其中24 h尿蛋白量与Scr差异具有非常显著性意义(P<0.01)。结论茶多酚片是一种有效治疗慢性肾小球肾炎的药物。该方法治疗效果显著,临床治疗过程中未发现严重不良反应,值得广泛推广和深入研究。

Objective To explore the clinical effect of added tea polyphenol tablet in the adjuvant treatment of chronic glomerulonephritis. Methods The 70 patients with primary chronic glomerulonephritis treated from December 2012 to November 2014 in author＇s hospital were selected and randomly divided into treatment group and control group, 35 cases for each group. Based on the basis clinical therapies of control group,treatment group received added tea polypheno] tablet;the curative effect of two groups was compared. Results In treatment group 21 cases were cured,13 got improved,the effective rate was 97.1%;while,in control group 9 cured,14 improved,the effective rate was 65.7%. The effective rate of treatment group was very significantly higher than that of control group （P〈0.01）;compared with the indexes before treatment,such as 24 h urine protein,Ser and BUN,that after treatment were significantly different （P〈0.05）;after treatment,the index of treatment group was better than that of control group （P〈0.05）;the index of 24 h urine protein was significantly different from the index of Scr （P〈0.05）. Conclusion The tea polyphenol tablet is an effective drug in the treatment of chronic glomerulonephritis. It has an obvious effect and has no severe adverse reactions during clinical treatment. It is worthy of extensive promotion and deep research.