长效干扰素联合利巴韦林治疗慢性丙肝临床观察

Interferon combined with Leigh Bhave Lin clinical observation on the treatment of chronic hepatitis C

目的:探讨长效干扰素联合利巴韦林治疗慢性丙肝临床效果。方法:2013年5月-2014年6月某医院收治的110例慢性丙肝患者作为研究对象,将2014年以前收治的55例患者设为对照组,采用普通干扰素联合利巴韦林治疗,将2014年后收治的55例患者设为观察组,采用长效干扰素联合利巴韦林治疗,对比观察组患者和对照组患者的应答率及不良反应状况。结果:观察组患者的总应答率与对照组相比明显较高(P<0.05)。观察组患者脱发发生率与对照组相比无显著差异(P>0.05)。观察组患者中性粒细胞减少发生率与对照组相比无显著差异(P>0.05)。观察组患者流感样症状发生率与对照组相比明显较高(P<0.05)。结论:长效干扰素联合利巴韦林治疗慢性丙肝能有效提高应答率,可在临床中推广运用。

Objective：To investigate the clinical effect of interferon combined with Leigh Bhave Lin in the treatment of chronic hepatitis C.Methods： in our hospital from 110 cases of patients with chronic hepatitis C as the research object, 2014 years ago from 55 cases of patients as control group, using ordinary interferon plus ribavirin therapy, after 2014 from 55 cases of patients were divided into the observation group, treated with pegylated interferon and ribavirin were observed and compared group and control group, the response rate and adverse reaction condition.Results：the total response rate in the observation group was significantly higher than that in the control group（P〈0.05）.Conclusion：interferon combined with Leigh Bhave Lin in the treatment of chronic hepatitis C can effectively improve the response rate, can be popularized in clinical use.