抗抑郁药结合认知行为疗法对产后抑郁症的影响

Effect of antidepressants combined with cognitive behavior therapy on postpartum depression

目的 探讨抗抑郁药结合认知行为疗法治疗产后抑郁症的临床效果。方法 选择2014年12月~2015年12月于浙江省温州医科大学附属康宁医院诊断为产后抑郁的患者60例为研究对象,按照入院单双号分为研究组和对照组,每组各30例。两组患者均给予抗抑郁药治疗,研究组在此基础上给予认知行为疗法治疗。比较两组的临床疗效。结果 治疗后两组SCL-90评分各维度得分均显著低于治疗前,差异有高度统计学意义（P〈0.01）;治疗后研究组患者SCL-90评分均显著低于对照组,差异有高度统计学意义（P〈0.01）。两组治疗后HAMD评分均显著下降,与干预前比较差异有高度统计学意义（P〈0.01）;治疗后2、4周及8周,研究组HAMD评分显著低于对照组,差异有统计学意义（P〈0.05或P〈0.01）。治疗后研究组DAS评分显著低于治疗前,差异有高度统计学意义（P〈0.01）;治疗后研究组DAS评分显著低于对照组,差异有高度统计学意义（P〈0.01）。研究组显效率、有效率均显著高于对照组,差异均有统计学意义（P〈0.05或P〈0.01）。结论 抗抑郁药结合认知行为疗法对产后抑郁症患者具有显著的临床疗效,值得临床推荐。

Objective To discuss effect of antidepressants combined with cognitive behavior therapy on postpartum depression. Methods Sixty cases with postpartum depression from December 2014 to December 2015 in Corelle Hospital, Wenzhou Medical University were selected as research objects, and they were divided into study group and control group according to even and odd-numbered admission, with 30 cases in each group. Patients of the two groups were treated with antidepressants, and the study group was treated with cognitive behavior therapy in addition. Clinical efficacy of two groups was compared. Results After treatment, each dimension score of SCL-90 of two groups was lower than that before treatment, the difference was statistically significant （P 〈 0.01）; each dimension score of SCL-90 of study group after treatment was lower than that of the control group, the difference was statistically significant （P 〈 0.01）. HAMD scores of two group after treatment were lower than those before treatment, the differences were statistically significant （P 〈 0.01）; HAMD score of the study group was lower than that of the control group 2 weeks, 4 weeks and 8 weeks after treatment, the differences were statistically significant （P 〈 0.01）. DAS score of study group after treatment was lower than that before treatment, the difference was statistically significant （P 〈 0.05 or P 〈 0.01）. DAS score of study group after treatment was lower than control group, the difference was statistically significant （P 〈 0.01）. Significant effective rate and general effective rate of study group were higher than those of the control group, the differences were statistically significant （P 〈 0.05 or P 〈 0.01）. Conclusion Antidepressants combined with cognitive behavior therapy for postpartum depression can improve clinical efficacy, worthy of clinical promotion.