复方番石榴制剂治疗超重肥胖2型糖尿病的疗效分析

Therapeutic Effect of Compound Fanshiliu Recipe for Over-weighted Type 2 Diabetes Mellitus

【目的】评价复方番石榴制剂治疗超重肥胖2型糖尿病的临床疗效。【方法】将120例超重肥胖2型糖尿病患者随机分为治疗组和对照组各60例,治疗组给予口服二甲双胍肠溶片及复方番石榴制剂治疗,对照组给予口服二甲双胍肠溶片治疗,疗程均为12周。观察2组治疗前后腰围(WC)、体质量指数(BMI)、空腹血糖(FBG)、餐后2h血糖(P2hBG)、糖化血红蛋白(HbA1c)、胆固醇(TC)、甘油三酯(TG)、游离脂肪酸(FFA)等的变化情况,评估复方番石榴制剂的临床疗效。【结果】(1)中医证候总疗效:治疗后,治疗组的总有效率为95.00%,优于对照组的70.00%,差异有统计学意义(P<0.01)。(2)治疗后,治疗组的WC和BMI均较治疗前显著下降(P<0.01),而对照组均无明显下降(P>0.05),治疗组对WC和BMI的下降作用均优于对照组(P<0.05)。(3)治疗后,2组FBG、P2hBG、HbA1c、TC、TG、FFA水平均较治疗前显著改善(P<0.05),且治疗组对上述各项指标的改善作用均优于对照组(P<0.05)。(4)安全性评价:除治疗组有3例患者出现轻度的胃部不适感,未予特殊处理后自行缓解外,其余患者均未发现不良反应。【结论】复方番石榴制剂联合二甲双胍治疗超重肥胖2型糖尿病,疗效确切,可有效降糖、降脂、减肥及改善中医证候。

Objective To evaluate clinical effect of Compound Fanshiliu Recipe（CFR） for the treatment of over-weighted type 2 diabetes mellitus（T2DM）. Methods One hundred and twenty over-weighted T2DM patients were randomized into treatment group and control group, 60 cases in each group. Both groups were given oral use of Metformin Hydrochloride Enteric-Coated Tablets, and additionally the treatment group was treated with CFR orally. The treatment of both groups lasted for 12 continuous weeks. Before and after treatment,we detected the waist circumference（WC）, body mass index（BMI）, and the levels of fasting blood glucose（FBG）,postprandial 2-hour blood glucose（P2hBG）,glycosylated hemoglobin（HbA1c）,total cholesterol（TC）,triglyceride（TG）,and free fatty acid（FFA）. The therapeutic effect of the two groups was also evaluated after treatment.Results（1） The total effective rate for traditional Chinese medical symptoms was 95.00% in the treatment group,and was 70.00% in the control group,the difference being significant（P〈0.01）.（2）After treatment,WC and BMI were decreased in the treatment group（P〈0.01 compared with those before treatment）,but had no significant decrease in the control group（P〈0.05）. The decrease of WC and BMI of the treatment group was superior to that of the control group（P〈0.05）.（3）After treatment,levels of FBG,P2hBG,HbA1c,TC,TG,and FFA of both groups were significantly improved（P〈0.05）,and the improvement of the treatment group was superior to that of the control group（P〈0.05）.（4） Three patients of the treatment group suffered from slight gastric discomfort,and the discomfort was relieved without any special treatment. Other patients of the two groups had no adverse reaction. Conclusion Treatment of CFR combined with Metformin has been proved to be an effective and safe approach to decrease blood glucose and blood lipid levels, promote weight loss, and ameliorate traditional Chinese medical symptoms.