大黄对脓毒血症的临床疗效及对炎症因子的影响

Clinical Effect of Rhubarb Root and Rhizome on Pyemia and the Effect on Inflammatory Factor

目的探讨口服大黄对脓毒血症患者的治疗作用,结合血清中炎症因子水平的变化,探讨大黄的作用机制。方法将59例脓毒血症患者随机分为对照组和研究组,对照组采取常规治疗,研究组在常规治疗基础上服用生大黄粉。观察治疗1天、7天后血浆中IL-6、TNF-α、PCT和CRP的变化,并对比两组的治疗有效率。结果研究组IL-6、TNF-α、PCT和CRP较对照组明显降低,治疗有效率高于对照组,差异有统计学意义(P<0.05)。结论大黄口服能够降低脓毒血症患者的炎症反应,值得临床推广。

Objective To investigate the effect of rhubarb root and rhizome on pyemia,and to investigate the mechanism of action based on the effect and the changes in the serum levels of inflammatory factors. Methods A total of 59 pyemia patients were randomly divided into control group and study group. The control group used conventional therapies,while the study group took orally rhubarb root and rhizome powder additionally to the conventional therapies. The changes in the plasma levels of IL-6,TNF-α,PCT and CRP were observed at 1d and7 d after the treatments,and the effective rate was compared between the two groups. Results The study group had significantly lower plasma levels of IL-6,TNF-α,PCT,and CRP,and the effective rate of the study group was higher than that of the control group（ P〈0. 05）. Conclusion Oral use of rhubarb root and rhizome can lighten the inflammatory reaction in pyemia patients,and is worthy of clinical application.