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维拉佐酮关键中间体合成研究进展 被引量：2

The Synthesis Development of the Key Intermediate of Vilazodone
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摘要 5-(哌嗪-1-基)苯并呋喃-2-酯基或酰胺化合物是抗抑郁药维拉佐酮的关键中间体。综述了5-(哌嗪-1-基)苯并呋喃-2-酯基或酰胺化合物几种有代表性的合成路线,并通过不同的反应类型对哌嗪环的引入进行了论述。 5-（1-piperaziny）benzofuran-2-ester group or amide group compound is an important intermediate of antidepressant Vilazodone. This article summarized some representative synthetic routes of 5-（1-piperaziny）benzofuran-2- ester group or amide group compound, and discussed the different methods for introduction of piperazine ring.
作者 周露
机构地区 浙江工业大学药学院
出处 《浙江化工》 CAS 2016年第8期9-11,29,共4页 Zhejiang Chemical Industry
关键词 维拉佐酮 中间体 合成 哌嗪 Vilazodone intermediate synthesis piperazine
分类号 TQ460.4 [化学工程—制药化工]
  • 相关文献

参考文献12

  • 1李赛,宫平.维拉佐酮盐酸盐[J].中国药物化学杂志,2011,21(4):329-329. 被引量：2
  • 2宗利,郭文娟.一种5-(哌嗪-1-基)苯并呋喃-2-羧酸乙酯的合成方法:CN,103965148[P].2014-08-06.
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二级参考文献22

  • 1US Food and Drug Administration. Drug approval package Vi- ibryd( vilazodone hydrochloride ) tablets [ EB/OL ] : [ 2011 - 01-21 ]. http://www, fda. gov/NewsEvents/Newsroom/ PressAn-Nouncements/ucm240642. htm.
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  • 3US Food and Drug Administration. Drug approval package Vi- ibryd( vilazodone hydrochloride ) tablets [ EB/OL ]. [ 2011 - 01 -21 ]. http:/www, fda. gov/downloads/Drugs/DrugSafe- ty/UCM 241524.
  • 4pdf. US Food and Drug Administration. Drug approval package Vi- ibryd ( vilazodone hydrochloride) tablets [ EB/OL ]. [ 2011 - 01 -21 ]. http ://www. accessdata, fda. gov/drugsatfda docs/ label/2011/022567 s0001 bl. pdf.
  • 5HEINRICH T,BOETTCHER H,GERICKE R,et al.Synthesis and structure-activity relationship in a classof indolebutylpiperazines as dual 5-HT1A receptor ago-nists and serotonin reuptake inhibitors[].Journal of Medicinal Chemistry.2004
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二级引证文献7

浙江化工
2016年 第8期

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