咖啡酰基类衍生物的合成及其生物活性研究

Research Progress on Synthesis and Bioactivity of Caffeoyl Derivatives

咖啡酰基衍生物广泛存在于天然产物中,具有广谱的抗肿瘤活性,也具有抗炎、抗氧化、抗菌、抗HIV-1等生物活性,同时具有低毒、抗耐药、易制备等优点,近年来深受科研工作者关注,对咖啡酰基衍生物的合成方法和生物活性研究进展进行综述。

Caffeoyl derivatives are widely distributed in natural products,which show a broad spectrum of anti-tumor activities and anti-oxidation and antibacterical activities.These caffeoyl derivitives have the advantages of low toxicity, anti-drug-resistant, easy preparation, which attracted more attention in recent years.In this paper, the synthesis and biological activity of advances in the coffee acyl derivatives were reviewed.