注射用丹参多酚酸治疗轻中度缺血性脑卒中的有效性及安全性

The effectiveness and safety of salvianolic acid injection in treating mild- to- moderate ischemic cerebral stroke

目的:评价注射用丹参多酚酸治疗轻中度缺血性脑卒中的有效性和安全性。方法:2013年6月至2015年6月,选取我科轻中度缺血性脑卒中住院患者160例,随机分为两组,使用注射用丹参多酚酸及基础药物治疗组100例患者为观察组,使用丹红注射液及基础药物治疗组60例患者为对照组,两组各用药14 d,评估用药前及用药7 d、14 d的美国国立卫生院卒中量表(national institue of health stroke scale,NIHSS)评分,记录观察组用药前及用药14 d肝、肾功能及心肌酶结果并分析。结果:1.两组患者用药前后NIHSS评分比较均有统计学差异(P<0.05)。2.两组患者组间用药前及用药第7 d进行NIHSS评分比较无统计学差异(P>0.05),用药14 d时NIHSS评分对比差异具有统计学意义(P<0.05)。3.观察组用药前后肝、肾功能及心肌酶结果比较差异无统计学意义(P>0.05)。结论:注射用丹参多酚酸对轻中度缺血性脑卒中治疗有效,对肝、肾功及心肌酶影响小,临床应用比较安全。

Objective： To evaluate the effectiveness and safety of salvianolic acid injection in treating mild- to- moderate cerebral stroke.Methods： 160 patients with mild- to- moderate stroke who used salvianolic acid injection in The 2nd Department of Neurology of the 1st Affiliated Hospital of Baotou Medical College were collected from June 2013 to June 2015 and were randomly divided into two groups,with 100 patients in the observation group（ treated with salvianolic acid injection and essential medicine） and 60 patients in the control group（ treated with Danhong injection and essential medicine）. The patients in the two groups were treated for 14 days. National institue of health stroke scale（ NIHSS） scores were evaluated before treatment,on the 7th day and on the 14 th day in the two groups respectively. The data of liver function,kidney function and myocardial enzyme before and after the treatment in the observation group were recorded. Results： 1. There was difference in terms of NIHSS scores of the two groups before and after the treatment（ P〈0. 05）. 2. There was no difference between the two groups in terms of NIHSS before the treatment and the 7th day of treatment（ P〉0. 05）; there was difference after the 14 th day of treatment（ P〈0. 05）. 3. There was no difference in terms of liver function,kidney function and myocardial enzyme before and after the treatment in the observation group（ P〉0. 05）. Conclusion：Salvianolic acid injection is effective in treating patients with mild- to- moderate ischemic cerebral stoke and it has little influence in hepatic function,renal function,myocardial enzymes,which is relatively safe in clinical application.