摘要
目的:探讨半乳凝素-3(Galectin-3)在宫颈上皮瘤变(CIN)、宫颈鳞状细胞癌组织中的表达及其意义。方法:选择80例宫颈鳞状细胞癌组织标本、60例CIN标本及20例正常宫颈组织标本作为研究对象,采用免疫组化法检测组织中Galectin-3蛋白表达,观察不同CIN分级及宫颈鳞状细胞癌患者的分化程度、病灶大小、是否发生淋巴转移、年龄及临床分期与Galectin-3蛋白阳性表达率的关系。结果:3组Galectin-3蛋白阳性表达率比较,宫颈鳞状细胞癌组织中显著高于CIN和正常宫颈组织(P<0.05),CIN组织和正常宫颈组织差异无统计学意义(P>0.05);不同CIN分级患者组织中Galectin-3蛋白阳性表达率比较,差异无统计学意义(P>0.05);宫颈鳞癌组织中Galectin-3蛋白阳性表达率在低分化、病灶≥2cm及癌细胞未发生淋巴转移患者中显著升高,差异有统计学意义(P<0.05);在不同年龄和不同临床分期患者间比较,差异无统计学意义(P>0.05)。结论:宫颈鳞癌组织中Galectin-3蛋白阳性表达率显著增高,与患者的癌细胞的分化程度、病灶大小及淋巴结转移有关。
Objective: To investigate the expression and significance of-3 (Galectin-3) in cervical squamous cell carcinoma (CIN) and cervical squamous cell carcinoma (SCC). Methods: 80 cases of cervical squamous cell carcinoma tissue specimens and 60 cases of CIN tissues, 20 cases of normal cer- vical tissue specimens were collected, using immunohistochemical method to detect the expressive in- tensity of galectin-3 in three groups, and analyzing galectin-3 protein and cervical squamous cell carci- noma patients clinical pathological features. Results: In squamous cell carcinoma of cervix galectin-3 protein positive expression rate was 82.50% significantly than 31.67% in CIN tissues and normal cer- vical tissues of 35.00% , the difference has statistical significance ( P 〈 0.05 ) ; normal cervical tissue and CIN and galectin-3 protein positive expression rate differences had no statistical significance (P 〉 0.05 ). Cervical squamous cell carcinoma in galectin-3 protein positive expression rate in patients with different degree of differentiation, tumor size, whether lymph node metastasis has a statistically signifi- cant relationship (P 〈 0.05 ), and the age of patients, the clinical staging was not significant (P 〉 0. 05 ). Conclusion: The positive expression rate of Galectin-3 protein in cervical squamous cell carci- noma was significantly increased, and it had a certain relationship with the degree of differentiation, the size of the lesion and lymph node metastasis.
出处
《贵阳医学院学报》
CAS
2016年第8期967-970,共4页
Journal of Guiyang Medical College
关键词
半乳凝素-3
宫颈上皮瘤变
宫颈鳞状细胞癌
免疫组织化学
淋巴转移
肿瘤分期
Galectin-3
cervical intraepithelial neoplasia
cervical squamous cell carcinoma
immu-nohistochemistry
lymphnode metastasis
tumor stage