血清前白蛋白水平与急性心肌梗死患者冠脉病变程度的相关性

Correlation between the Level of Serum Pre albumin （PAB） and the Degree of Coronary Artery Disease in Patients with Acute Myocardial Infarction （AMI）

[目的]探讨急性心肌梗死（AMI）患者血清前白蛋白（PAB）水平与冠脉病变程度的相关性。[方法]选择2012年6月至2015年6月本院收治的194例AMI患者作为观察组，以同期于本院行常规体检无心血管疾病的58例健康者为对照组。观察两组以及观察组内不同程度血管病变患者血清PAB水平，并分析血清PAB水平与AMI冠脉病变的相关性。[结果]与对照组相比，观察组患者入院时PAB水平明显降低，GRACE评分明显提高，组问比较差异均具有统计学意义（P〈0．05）。观察组不同程度血管的病变的PAB水平单支组〉双支组〉三支组，而GRACE评分为单支组〈双支组〈三支组，组间比较均具有统计学意义（P〈0．05）。观察组中发生心血管事件136例，与未发生心血管事件患者相比其入院时PAB水平较高，GRACE评分较低，差异具有统计学意义（P〈0．05）。经spearman相关分析，PAB水平与AMI病变程度（r=-0．202，P〈0.05）、GRACE危险评分（r=-0．236，P〈0.05）以及心血管事件的发生均呈负相关（r=-0．211，P〈0．05）。[结论]AMI患者血清PAB水平与冠脉病变程度及其预后均具有相关性，可作为早期诊断治疗和判断预后的参考指标。

[Objective]To investigate the correlation between the level of serum pre albumin （PAB） and the degree of coronary artery disease in patients with acute myocardial infarction （AMI）.[Methods]One hun- dred and ninety-four cases of acute myocardial infarction patients treated in our hospital from June 2012 to June 2015 as were selected as observation group, and 58 cases of health persons with routine checkup in hospital without cardiovascular disease in same period as control group. The levels of serum PAB were observed in two groups of patients with different degree of vascular disease, and the correlation between serum PAB level and AMI coronary artery disease was analyzed.[Results]Compared with control group, the PAB level of patients in observation group on admission was significantly decreased, and GRACE score was increased significantly, the comparison between groups were statistically significant （ P〈0.05）. Depending on the different degree of pathological changes, the PAB level in the observation groups presented that the single coronary artery lesion group the double coronary artery lesions group 〉 the triple coronary artery lesions group, the comparison between the groups was statistically significant （ P〈0.05） . 136 cases of cardiovascular events occured in the observation group, and compared patients without cardiovascular events the PAB level was higher, and GRACE score was lower, the difference was statistically significant （ P〈0.05）. The spearman correlation a- nalysis showed that PAB level had a negative correlation with the degree of the AMI lesions （ r =0.202, P〈 0.05） , the GRACE risk score （r =0.236, P〈0.05） and the incidence of cardiovascular events （r = -0.211, P〈0.05）. [Conclusion] The serum prealbumin level of patients with acute myocardial infarction was related with pathological degree and prognosis , so it can be used as a reference index of early diagnosis and treatment, and prognosis judgment.