多药联用综合治疗高血压合并糖尿病的临床疗效研究

Clinical Efficacy and Prognosis Analysis of Drug Combination Therapy for Hypertension Com- plicated with Diabetes

[目的]探讨多药联合综合治疗高血压合并糖尿病的临床疗效。[方法]选取2015年6月至2016年6月本院收治的高血压合并糖尿病的患者94例，应用随机数字表法分为观察组与对照组，对照组患者给予常规降压药物治疗，治疗组患者采用多药联用综合治疗，对比两组患者的临床疗效，并对比治疗前后两组患者的收缩压（SBP）、舒张压（DBP）、空腹血糖（FPG）、血尿素氮（BUN）、血清肌酐（SCr）、血清钾（K＋）及尿酸（UA）等变化。[结果]与对照组对比，观察组患者的总有效率为93．62％显著高于对照组的85．11％，差异有统计学意义（χ2=8．732，P〈0．05）；与治疗前对比，治疗后两组患者的SBP、DBP及FPG水平均明显改善，且观察组患者的SBP、DBP及FPG水平较对照组患者改善更明显（P〈0．05）；与治疗前对比，治疗后观察组患者的BUN及SCr均显著改善（P〈0．05），但UA及K＋水平无显著改善，且两组比较无显著差异（P〉0．05）。[结论]多药联合综合治疗高血压合并糖尿病疗效显著，可有效控制患者病情，值得临床推广。

[ObjectivelTo explore the clinical efficacy of comprehensive treatment of hypertension compli- cated with diabetes by drug combination.[Methods]Ninety-four cases with hypertension complicated with dia- betic in our hospital from June 2015 to 2016 June were selected and divided into treatment group and control group according to the random number table method. Patients in the control group received conventional anti- hypertensive drug treatment, while those in the treatment group were treated with the drug in combination with comprehensive treatment. The clinical efficacy of the two groups was compared. Changes of systolic blood pressure （SBP）, diastolic blood pressure （DBP）, fasting blood glucose （FPG）, blood urea nitrogen （BUN）, serum creatinine （SCr）, serum potassium （K＋） and uric acid （UA） of the two groups of patients before and after treatment were compared with.[Results]Compared with the control group, the total effective rate of the treatment group was 93.62 %, significantly higher than that of the control group （85.11% ）, the difference was statistically significant （χ2= 8.732, P 〈0.05）; Compared with those before treatment, the levels of FPG, DBP and SBP were significantly improved in the two groups after treatment, and SBP, DBP and FPG levels in the treatment group were significantly better than those in the control group （ P 〈 0.05） Compared with those before treatment, BUN and SCr in the treatment group were significantly improved after treatment （ P 〈0.05） ; But there was no significant improvement in UA and K＋ levels, and there was no significant differ- ence between the two groups （ P〉0.05）.[ConclusionlComprehensive treatment of hypertension complicated With diabetes by drug combination has obvious curative effect, and can effectively control the patient＇s condi- tion. It is worthy of clinical promotion.