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微小RNAs调控低氧诱导因子-1α/2α与低氧肺动脉高压

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摘要 肺动脉高压（pulmonary hypertension，PH）临床病因复杂，由心血管、呼吸等疾病引起肺血管病理生理紊乱发展而来。PH形成主要的原因是肺动脉平滑肌细胞（pulmonary arterial smooth muscle cells，PASMCs）、肺血管内皮细胞（pulmonaryartery endothelial cells，PAECs）等血管形成细胞的增殖或迁移而致肺血管管腔进行性狭窄或闭塞、肺血管重建和血管收缩反应增强，最终发展为右心衰竭甚至死亡。
作者 余震坤 韩永建 常荣
机构地区 青海大学医学院 青海省人民医院心血管内科
出处 《重庆医学》 CAS 北大核心 2016年第26期3716-3719,共4页 Chongqing medicine
基金 国家自然科学基金资助项目(81360301) 青海省应用基础研究计划资助项目(2013-Z-743)
关键词 微小RNAS 低氧诱导因子 低氧肺动脉高压
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献26

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重庆医学
2016年 第26期

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