浅析丙基硫氧嘧啶诱发抗中性粒细胞胞浆抗体(ANCA)阳性血管炎104例

Analysed 104 cases of the PTU arise the Anti neutrophil cytoplasm antibodies(ANCA) positive vasculitis

目的对服用丙基硫氧嘧啶(PTU)后诱发的抗中性粒细胞胞浆抗体(ANCA)阳性血管炎的临床病例特点和治愈方法进行研究分析。方法对近15年国内文献报道的104例PTU诱发阳性血管炎的病例进行分析。结果丙基硫氧嘧啶诱发抗中性粒细胞胞浆抗体(ANCA)阳性血管炎,女性病例比较多,症状主要为身体器官受损,例如肾部和肺部是受损率最高的部位。结论丙基硫氧嘧啶诱发抗中性粒细胞胞浆抗体(ANCA)阳性血管炎,症状发生的周期和丙基硫氧嘧啶服用的时间和用量有直接关系,也可采取及时应用糖皮质激素来控制症状的发生。

Objective This papers discusses the features of clinical cases and the treatment of the condition after the patients takes the PTU arising the Anti neutrophil cytoplasm antibodies （ANCA） positive vasculitis. Methods This paper will analyze 104 clinical cases of positive vasculitis which is aroused by the propyhhiouracil （PTU）. Results Propylthiouracil（PTU） arises the ANCA positive vasculitis,and most of the patients are female. The main symptom is the damage of the body organ. For example,the kidney and lung have the highest damage ratio. Conclusion Propyhhiouracil （PTU） arises the（ANCA） positive vasculitis ,and the interval of the symptom is directly related to the quantity and the length of taking the propylthiouracil（PTU）. Taking glucocorticoids can help to control the symptom.