Ⅱ型固有淋巴细胞在支气管哮喘发病机制中作用的研究进展

Roles of type 2 innate lymphoid cells in the pathogenesis of bronchial asthma

Ⅱ型固有淋巴细胞（type 2 innate lymphoid cells,ILC2s）是新近发现的一类固有免疫细胞,属于固有淋巴细胞家族。 ILC2s在IL-25和IL-33的刺激下可以产生IL-5、IL-13等Th2型细胞因子,在哮喘等变态反应的发病机制中发挥着重要作用。对ILC2s的进一步研究可以推进我们对哮喘疾病的认识,为过敏性哮喘的治疗开辟新的途径。本文就Ⅱ型固有淋巴细胞的来源、分布、生物学功能及其在支气管哮喘中的作用和临床价值做一综述。

Type 2 innate lymphoid cells （ ILC2s） are recently identified members of the innate lymphoid cell （ ILC） family. These cells are capable of producing Th2-type cytokines such as IL-5 and IL-13 in response to epithelial cell-derived cytokines IL-25 and IL-33 and play critical roles in allergic diseases such as bronchial asthma. Further investigations on ILC2s will enhance the better understanding of type 2 immune responses and may provide new strategies for the treatment of allergic asthma. In this review, we fo-cus on the origin, location and biological function of ILC2s as well as their possible roles in the pathogenesis of bronchial asthma.