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转录因子SOX18研究进展 被引量：2

Research progress of transcription factor SOX18
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摘要 性别决定区Y框18[SRY(sex determining region Y)-box 18,SOX18]是一种转录因子,属于SRY相关基因,常表达于生长中的脉管系统,参与血管、淋巴管发育过程,其基因突变或异常表达与许多体内肿瘤发生发展有关。 SOX18 ,a member of the SOX gene family （ SRY-like 3-hydroxy-3-nlethylglutaryl box gene） ,is a transcription factor expressed in the development of the vascular system, which is involved in the regulation of blood vessels and lymphatic vessels development. SOX18 gene mutation or abnormal expression is related to tumorigenesis.
作者 朱凡河 石俊强
机构地区 济宁医学院基础学院 <济宁医学院学报>编辑部
出处 《济宁医学院学报》 2016年第4期280-282,287,共4页 Journal of Jining Medical University
基金 济宁医学院青年基金项目(编号:JYQ 2011KM 018)
关键词 SOX18 转录因子 血管生成 淋巴管生成 肿瘤 SOX18 Transcription factor Angiogenesis Lymphangiogenesis Cancer
分类号 Q75 [生物学—分子生物学]
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参考文献21

  • 1Jethon A, Pula B, Olbromski M, et al. Prognostic signifi- cance of SOX18 expression in non-small cell lung cancerJ]. Int J Onco1,2015,46( 1 ) :123-132.
  • 2石俊强.淋巴管生成与疾病[J].济宁医学院学报,2015,38(5):349-355. 被引量：3
  • 3Downes M, Koopman P. SOX18 and the transcriptional regulation of blood vessel development [ J ]. Trends Car- diovasc Med, 2001,11 ( 8 ) : 318-324.
  • 4Klaus M, Prokoph N, Girbig M, et al. Structure and de- coy-mediated inhibition of the SOX18/Proxl-DNA inter- action [ J ]. Nucleic Acids Res, 2016,44 ( 8 ) : 3922- 3935.
  • 5Zhou Y,Williams J,Smallwood P M, et al. Sox7, Soxl7, and Soxl8 Cooperatively Regulate Vascular Development in the Mouse Retina [ J ]. PLoS One, 2015,10 ( 12 ) : e0143650.
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二级参考文献20

  • 1Akhras V, Ramakrishnan R, Stanton A W, et al. Quantitative imaging in vivo of functioning lymphatic vessels around hu- man melanoma and benign nevi[J]. Microcirculation, 2015 Jun 11. doi:10. 1111/micc. 12216. [Epub ahead of print].
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  • 8Francois M,Caprini A, Hosking B,et al. Sox18 induces devel- opment of the lymphatic vaseulature in mice [J]. Nature, 2008,456(7222) : 643-647.
  • 9Wtinnemann F, Kokta V, Leclere S, et al. Aortic dilatation as- sociated with a de novo mutation in the SOX18 gene: expan- ding the clinical spectrum of hypotrichosis-lyrnphedema-tel- angiectasia syndrome[J]. Can J Cardiol, 2015 Apr 13. pii; S0828-282X(15)00280-00289. doi: 10. 1016/j. cjca. 2015.04. 004. [Epub ahead of print].
  • 10Deng Y, Simons M. Lymphatic fate specification : playing RAF with ERK[J]. Cell Cycle, 2013,12(8) :1157-1158.

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济宁医学院学报
2016年 第4期

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