氨溴特罗口服溶液联合孟鲁司特钠咀嚼片治疗儿童急性支气管炎疗效观察

The therapeutic efficacy of ambroxol hydrochloride and clenbuterol hydrochloride oral solution combined with montelukast sodium chewable tablets in children with acute bronchitis

目的探讨氨溴特罗口服溶液联合小儿孟鲁司特钠咀嚼片治疗急性支气管炎疗效。方法 选择我院儿科门诊确诊为急性支气管炎患儿220例,按就诊时间随机分为观察组和对照组各110例。对照组给予头孢克洛颗粒每日20 mg/kg,分3次给予及氨溴索口服溶液2~5岁：儿童：每次2.5 m L,每日3次;1~2岁儿童：每次2.5 m L,每日2次;观察组采用头孢克洛颗粒每日20 mg/kg及氨溴特罗口服溶液,1次2.5~15 m L,每日2次口服;孟鲁司特钠咀嚼片（顺尔宁）,每日1次,每次1片（4 mg）,疗程均7 d,两组治疗7 d后评价疗效。结果 观察组治疗有效率显著高于对照组（χ2=25.08,P〈0.01）;对照组发热时间,咳嗽时间,喘息时间及肺部啰音时间分别为（4.16±1.16）d、（6.41±1.34）d、（5.26±1.15）d、（6.28±1.31）d,观察组咳嗽时间,喘息时间及肺部啰音时间分别为（3.12±1.03）d、（5.36±1.71）d、（4.39±1.28）d、（5.26±1.26）d,两组比较差异有高度统计学意义（P〈0.01）。结论 氨溴特罗口服溶液联合孟鲁司特钠咀嚼片可显著缩短急性支气管炎发热时间、咳嗽时间、喘息时间及肺部啰音时间,值得推广应用。

Objective To explore the therapeutic efficacy of ambroxol hydrochloride and clenbuterol hydrochloride oral solution combined with montelukast sodium chewable tablets in children with acute bronchitis. Methods 220 children with acute bronchitis in out-patient of department of paediatrics in our hospital, according to the treatment time were divided into the control group（n=110） and the observation group（n=110）. Patients in the control group were taken gran- ules cefaclor 20 mg/kg 3 times a day and Ambroxol oral solution： children aged 2-5：2.5 mL each time, 3 times a day; children aged 1-2：2.5 mL each time, 2 times a day. Patients in the observation group were taken granules cefaclor 20 mg/kg 3 times a day,Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution 2.5-15 mL a time 2 times a day and montelukast sodium chewable Tablets one tablet （4 mg） each time, 1 time a day. The courses of treatment in both groups were 7 days and therapeutic effects were evaluated after 7 days. Results The effective percentage in the observation group was significantly higher than that in the control group（x2=25.08, P〈0.01）. The clinical data were com- pared between the two groups. The fever time,cough time, wheezing time, rale time in the control group were （4.16± 1.16）d, （6.41± 1.34）d, （5.26±1.15）d, （6.28± 1.31）d, respectively, and The fever time, cough time, wheezing time, rale time in the observation group were （3.12±1.03）d,（5.36±1.71）d, （4.39±1.28）d, （5.26±1.26）d respectively, there were signifi- cant differences between the two groups（P〈0.01）. Conclusion Ambroxol hydrochloride and clenbuterol hydrochloride o- ral solution combined with montelukast sodium chewable tablets can significantly shorten the duration of fever, acute bronchitis and cough, wheezing and lung rale of acute bronchitis, and which deserves popularization and application.