奥卡西平混悬液治疗儿童癫痫部分性发作的临床观察

Effects of oxcarbazepine in treatment of children with partial seizure epilepsy

目的:观察奥卡西平混悬液治疗儿童癫痫部分性发作的临床效果及对患儿脑电活动的影响。方法:选择2010年1月至2011年1月在我院接受治疗的部分性发作癫痫患儿80例,随机分为观察组与对照组,各40例。观察组患儿采用奥卡西平混悬液治疗,对照组患儿采用卡马西平治疗。观察并比较两组临床效果及患儿脑电活动情况。结果:治疗后,两组患儿脑电图θ波均明显高于治疗前(P<0.05);而α波与治疗前相比有所降低;两组临床疗效及脑电图活动比较,差异无统计学意义(P>0.05)。结论:对部分性发作癫痫患儿奥卡西平与卡马西平的临床疗效相当,但奥卡西平对患儿脑电背景活动的影响相对较小。

Objective： To observe the effects of oxcarbazepine（ OXC） suspension on the treatment of partial seizure epilepsy in children and it＇s influences on brain electrical activity. Methods： Eighty children with epilepsy seizures who were treated in our hospital from Jan 2010 to Jan 2011 were selected and randomly divided into the observation group and the control group,40 in each. The patients of the observation group were treated with OXC while the patients of the control group were treated with carbamazepine（ CBZ）. Then clinical efficacy and EEG activity were observed and compared between the two groups after treatment. Results： After the treatment,the θwave of both group were higher than before（ P〈0. 05）; but α wave was lower than before. The clinical effect and EEG activity after treatment were compared between two groups,and there was no statistically significant difference（ P〉0. 05）. Conclusion： OXC and CBZ have consistent effect on the treatment of children with a partial seizures,but the OXC has less effect on EEG background activities.