中西医结合治疗糖尿病肾病的临床研究

Clinical Study on the Treatment of Diabetic Nephropathy With Combination of Traditional Chinese And Western Medicine

目的:观察非洛地平片联合五苓散加减治疗糖尿病肾病的临床疗效,探讨中西医结合治疗糖尿病肾病的优势。材料与方法:纳入l20例糖尿病肾病患者,随机分为对照组和治疗组,在运用基础降糖治疗基础上,两组均使用非洛地平片降压,治疗组加用五苓散加减,疗程为2个月。重点观察患者尿微量白蛋白排泄率(UAER)的变化,并观察患者血肌酐(Scr)、尿素氮(BUN)、尿酸(UA)、平均动脉压均(MAP)及糖化血红蛋白的变化。结果:治疗组总有效率为96.7%,明显优于对照组(P<0.01);治疗2月后尿微量白蛋白排泄率(UAER)及血肌酐(Scr)均有所改善,治疗组优于对照组(P<0.01);而在糖化血红蛋白、尿素氮(BUN)、尿酸(u A)及平均动脉压均(MAP)方面具有不同程度的改善,但组间对比(P>0.05)差异不大,结论:两组均有改善糖尿病肾病患者的微量白蛋白尿排泄率。而中西医结合(非洛地平联合五苓散加减)的治疗方法效果更明显:

Purpose： To observe the clinical efficacy of felodipine tablets combined with Wuling powder Decoction in the treatment of diabetic nephropathy（ DN） and investigate the advantage of combination of traditional Chinese and Western Medicine. Materials and Methods： 120 patients with DN were randomly divided into control group and treatment group. On the basis of the use of basic hypoglycemic therapy,patients in both group took Felodipine Tablets to control blood pressure while patients in the treatment group were additionally treated with Wuling powder Decoction for 2 months. The changes of urinary albumin excretion rate（ UAER）,serum creatinine（ Scr）,blood urea nitrogen（ BUN）,uric acid（ UA）,mean arterial pressure（ MAP） and glycosylated hemoglobin were observed. Results： The total effective rate of the treatment group was96. 7%,which was significantly better than that of the control group（ P 0. 01）. The UAER and Scr were improved after treatment for 2 months,and the treatment group was better than the control group（ P 0. 01）. While glycosylated hemoglobin,BUN,UA and MAP were improved in different degrees,no significant difference was found between the two groups（ P 0. 05）. Conclusion： The UAER was improved in both groups,but the curative effect of combination of traditional Chinese and Western Medicine（ felodipine tablets combined with Wuling powder Decoction） is more remarkable.