益肾泻浊方对维持性血液透析患者微炎症状态的影响

Clinical Observation of the Effect of Yishen Xiezhuo Recipe on the Microinfl ammatory State in Maintenance Hemodialytic Patients

目的:观察益肾泻浊方对维持性血液透析患者微炎症状态的影响。方法:将60例维持性血液透析患者随机分为两组,对照组给予常规血液透析,观察组在对照组的基础上内服益肾泻浊方,两组疗程均为3个月,观察两组治疗前后血清超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、血红蛋白、血清总胆固醇、白蛋白水平的变化。结果:观察组治疗后hs-CRP、IL-6降低,差异具有统计学意义(P<0.05),TNF-α有降低,但差异均无统计学意义(P>0.05);对照组治疗后hs-CRP、IL-6、TNF-α均高于治疗前,但差异均无统计学意义(P>0.05)。观察组与对照组治疗后的组间比较,观察组hs-CRP、IL-6、TNF-α均低于对照组,差异具有统计学意义(P<0.05)。结论:益肾泻浊方能够抑制维持性血液透析患者的微炎症状态,改善其营养不良状态。

Objective To observe the effect of Yishen Xiezhuo Recipe on the microinflammatory state in maintenance hemodialytic patients. Methods 60 cases of maintenance hemodialytic patients were randomly divided into two groups. The control group was given conventional hemodialysis, while the observation group was given Yishen Xiezhuo Recipe plus conventional hemodialysis. The levels of high-sensitivity C-reactive protein（hs-CRP）, interleukin-6（IL-6）, tumor necrosis factor-α（TNF-α）, hemoglobin（Hb）, total cholesterol（TC）, and albumin（Alb） were detected before and after 3 months of treatment. Results In observation group, the levels of IL-6 and hs-CRP were significantly decreased after treatment（P〈0.05）. The level of TNF-α was also decreased, but it was not significantly. In control group, the levels of hs-CRP, TNF-α and IL-6 were higher after treatment, but without statistical significance. The levels of hs-CRP, TNF-α and IL-6 after treatment in observation group were significantly lower than those in control group（P〈0.05）. In observation group, the levels of Hb, TC and Alb were significantly increased after treatment（P〈0.05）. In control group, the levels of Hb, TC and Alb were increased without statistical significance. The levels of Hb, TC and Alb after treatment in observation group were significantly higher than those in control group（P〈0.05）. Conclusion Yishen Xiezhuo Recipe can inhibit the inflammatory state of maintenance hemodialytic patients and improve their nutritional state.