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高磷血症导致血管钙化的研究进展 被引量:8

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摘要 慢性肾脏病(chronic kidney disease,CKD)已成为威胁人类健康的主要疾病之一,心血管疾病(cardiovascular disease,CVD)是CKD患者死亡的主要原因,血管钙化是导致CKD患者心血管死亡率增加的独立危险因素。研究证实高磷血症可致血管钙化、
作者 李英
出处 《中国中西医结合肾病杂志》 2016年第8期659-661,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
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  • 1Eddington H, Hoefield R, Sinha S, et al. Serum phosphate and mortality in patients with chronic kidney disease. Clin J Am Soc Nephrol,2010,5 ( 12 ) :2251 - 2257.
  • 2Graciolli FG, Neves KR,dos Reis LM,et at. Phosphorus overload and PTH induce aortic expression of Runx2 in experimental u- raemia. Nephrol Dial Transplant ,2009,24(5 ) : 1416 - 1421.
  • 3Liu H, Li X, Qin F, et al. Selenium suppresses oxidative - stress -enhanced vascular smooth muscle cell calcification by inhibi- ting the activation of the PI3K/AKT and ERK signaling path- ways and endoplasmie retieulum stress. Journal of Biological In- organic Chemistry ,2014,19 ( 3 ) :375 - 388.
  • 4Byon CH, Javed A, Dai Q,et al. Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling. Journal of Biological Chemistry, 2008,283 ( 22 ) : 15319 - 15327.
  • 5Zhao MM, Xu MJ, Cai Y, et al. Mitochondrial reactive oxygen species promote p65 nuclear translocation mediating high - phosphate- induced vascular calcification in vitro and in vivo. Kidney Int,2011,79(10) :1071 - 1079.
  • 6Chavkin NW, Chia JJ, Crouthamel MH, et al. Phosphate uptake - independent signaling functions of the type III sodium - de- pendent phosphate transporter, PiT - 1, in vascular smooth mus- cle cells. Experimental Cell Research ,2015,333 ( 1 ) :39 - 48.
  • 7Yao L, Sun YT, Sun W, et al. High phosphorus level leads to aor- tic calcification via beta - catenin in chronic kidney disease. Am J Nephrol,2015,41 ( 1 ) :28 -36.
  • 8Martinez - Moreno JM, Munoz - Castaneda JR, Herencia C, et al. In vascular smooth muscle cells paricalcitol prevents phos- phate - induced Wnt/beta - catenin activation. Am J Physiol Re- nal Physiol,2012,303 (8) : F1136 - F1144.
  • 9Liu Y, Shanahan CM. Signalling pathways and vascular calcifica- tion. Front Biosci ( Landmark Ed) ,2011,16 : 1302 - 1314.
  • 10Gross P, Six I, Kamel S, et at. Vascular Toxicity of Phosphate in Chronic Kidney Disease. Circ J ,2014,78 (10) :2339 - 2346.

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