炎症性肠病患者睡眠质量调查及其影响因素分析

Sleep quality and influencing factors in patients with inflammatory bowel disease

目的 :调查炎症性肠病患者睡眠质量并分析其影响因素。方法 :采用匹兹堡睡眠质量指数量表(Pittsburgh Quality Sleep Index,PSQI)、疾病活动指数等工具收集炎症性肠病专科门诊就诊及肛肠科、消化科住院的120例患者资料。结果 :患者的睡眠障碍发生率高达55.8%(溃疡性结肠炎:47.6%,克罗恩病:64.9%)、PSQI平均(8.07±2.91)分,明显高于健康人群(P<0.05),其中主观睡眠质量(1.54±0.66)分、入睡时间(1.62±0.74)分、睡眠时间(1.16±0.71)分、睡眠效率(0.89±0.63)分、睡眠障碍(1.10±0.42)分、催眠药物(0.17±0.37)分、日间功能紊乱(1.59±0.76)分。经Stepwise多元回归法明确疾病活动期、无业(学习)、女性、接受激素类药物治疗是影响炎症性肠病患者睡眠质量的重要因素。结论 :炎症性肠病患者的睡眠质量低,与疾病活动性、工作/学习状态、性别及目前用药方案有关,临床应重视其中的关联性,将患者睡眠质量的评估纳入疾病管理方案中。

Objective： To investigate sleep quality and impact factors in patients with inflammatory bowel disease（IBD）. Methods： Totally 120 patients with inflammatory bowel disease were investigated. Participants completed a survey on socio-demographic characteristics, the Pittsburgh Quality Sleep Index （PSQI） and the Disease Activity Index （DAI）.Result：The incidence of sleep disorders in patients with inflammatory bowel disease was 55.8% （Ulcerative Colitis： 47.6%;Crohn＇s Disease： 64.9%）. The PSQI total score was 8.07±2.91, which was significantly higher than normal values （P〈0.05）.In decreasing order, the score of each domain of the PSQI was sleep latency （1.62±0.74）, subjective sleep quality （1.54±0.66）,sleep duration （1.16±0.71）, sleep disturbance （1.10±0.42）, sleep efficacy （0.89±0.63）, the use of sleeping medications（0.17±0.37）, the score of daytime dysfunction was 1.59±0.76. Stepwise regression analysis showed that active disease,unemployed, female and using hormonal drugs were related to sleep quality. Conclusion：Patients with IBD have poor sleep quality, which associate with DAI, the situation of work or study, gender and medication. Sleep quality evaluation should be considered as a part of inflammatory bowel disease management program.