降低血脂治疗稳定性心绞痛伴高脂血症的远期疗效观察

Long-term Curative Effect of Heart-protecting Musk Pill on Stable Angina pectoris accompanied by Hyperlipemia

目的:探讨麝香保心丸治疗稳定性心绞痛伴高脂血症的远期疗效。方法 :选取2013年3月-2016年2月在我院治疗的稳定性心绞痛伴高脂血症患者90例作为研究对象,随机分为观察组和对照组各45例,两组均在常规抗血小板、降低血压、稳定粥样硬化斑块、控制心率等治疗基础上,观察组给予:麝香保心丸45 mg,每日3次口服;对照组给予:单硝酸异山梨酯20 mg,每日1次口服,均连续治疗12个月。分别比较两组三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-c)的变化。结果:治疗前两组的TG,TC,LDL-c比较无明显差异(P>0.05);治疗3个月、6个月、12个月时观察组TG,TC,LDL-c均明显低于对照组,差异有统计学意义(P<0.05)。两组总有效率比较,观察组为86.67%,对照组为71.11%,差异有统计学意义(P<0.05)。结论:麝香保心丸治疗稳定性心绞痛伴高脂血症的临床疗效显著,远期效果较好,适合患者长期服用。

Objective： To investigate the long-term curative effect of heart-protecting musk pill in reducing blood lipid on stable angina pectoris. Methods： A total of 90 patients with stable angina companied by hyperlipidemia hospitalized in our hospital were selected as the research objects and randomly divided into observation and control groups, 45 for each. Based on the treatment of conventional antiplatelet, lowering blood pressure, stabilizing atherosclerotic plaque and controlling heart rate, the patients in observation group were treated with Heart-protecting musk pill at a dosage of 45 mg by oral route, 3 times a day, while those in control group with isosorbide 5-mononitrate at a dosage of 20 mg by oral route, once a day, for 12 months. The changes of TG, TC and LDL-c in the two groups were compared. Results： The TG, TC, LDL-c in observation groups showed no significant difference before treatment （P 〉 0.05）, while were significantly lower than those in control group 3, 6 and 12 months after treatment （each P 〈 0.05）. The total effective rates of trail and control groups were 86. 67% and 71. 11% respectively, which showed significant difference （P 〈 0. 05）. Conclusion： Heart-protecting Musk pills reduced blood lipid, and showed significantly curative effect on stable angina pectoris with hypeflipemia. It also showed good long-term effect and suitable for patients with long-term use.