摘要
目的:比较A型肉毒素注射与眶周全肌切除术治疗特发性眼睑痉挛的疗效。方法:前瞻性非随机对照试验。选取2010-12/2015-06间在我院实施A型肉毒素注射治疗的特发性眼睑痉挛患者30例60眼,同时选取年龄匹配的眶周全肌切除术治疗的特发性眼睑痉挛患者30例60眼,随访观察6mo,比较两组的疗效和复发率。结果:A型肉毒素注射治疗组完全缓解、明显缓解、部分缓解和无效的眼数分别为36眼(60.0%),20眼(33.3%)、2眼(3.3%)和2眼(3.3%)。眶周全肌切除术治疗组为16眼(26.7%),24眼(40.0%)、12眼(20.0%)和8眼(13.3%),两组比较差异有统计学意义(Z=-2.968,P=0.003)。治疗6mo后两组的复发率为93.3%和20.0%,比较差异有统计学意义(χ2=32.851,P<0.001)。结论:A型肉毒素注射治疗对于特发性眼睑痉挛疗效好,但6mo后容易复发。眶周全肌切除术疗效确定且长期疗效稳定,可作为A型肉毒素注射治疗后复发的有效治疗途径。
AIM: To compare the effectiveness of botulinus toxin of type A and complete resection of the periorbital muscle on idiopathic blepharospasm. ● METHODS: Patients with idiopathic blepharospasm and having undergone either of two procedures from Dec. 2010 to Jun. 2015 were selected ( 60 patients ) . Among them, group A (30 patients, 60 eyes) underwent botulinus toxin of type A, group B (30 patients, 60 eyes) underwent complete resection of the periorbital muscle. ●RESULTS: ln group A, the patients with complete response, obvious response, partial response, and no response were 36(60. 0%), 20(33. 3%), 2(3. 3%) and 2 (3. 3%) cases respectively. ln group B, the patients with complete response, obvious response, partial response, and no response were 16(26. 7%), 24(40. 0), 12(20. 0%) and 8 ( 13. 3%) cases respectively. The difference was statistically significant ( Z = - 2. 968, P = 0. 003 ). The relapse rate of group A and group B were 93. 3% and 20. 0% after 6mo, the difference was statistically significant (χ2=32. 851, P〈0. 001). ●CONCLUSION: The botulinus toxin injection of type A is effective for idiopathic blepharospasm. But recurrence rate is high after 6mo. Complete resection of the periorbital muscle have long-term efficacy for idiopathic blepharospasm. It′s a supplementary therapy after idiopathic blepharospasm recurrence.
出处
《国际眼科杂志》
CAS
2016年第10期1962-1964,共3页
International Eye Science
关键词
眼睑痉挛
肉毒毒素
眶周全肌切除术
疗效
idiopathic blepharospasm
botulinus toxin of type A
complete resection of the periorbital muscle
effect