有氧运动对被动吸烟大鼠生长性能和肺组织超微结构的影响

Influence of the Aerobic Exercise on Passive Smoking Rats' Growth Performance and Lung Tissue Ultrastructure

本实验旨在探讨有氧运动对被动吸烟大鼠的生长性能和肺部保护作用机制。方法:选取2月龄健康雄性大鼠32只,随机分为C、E、S、ES组。ES、E两组大鼠进行8周有氧运动干预;从第五周开始S、ES两组大鼠进行被动吸烟干预,剂量为8支/组/天。结果:与C相较,ES组大鼠体重变化非常明显(P<0.01);与E组相较,S组大鼠体重变化明显(P<0.05);与C相较,E、S、ES这四组大鼠肺和肺指数变化明显(P<0.05)。S、ES这两组大鼠肺组织出现大量炎症,其中尤以S组大鼠程度较重,而有氧运动干预时炎症程度较轻;C、E两组大鼠肺部也出现了少量炎症。结论:被动吸烟会延缓机体生长发育,有氧运动能刺激肺部生长发育;被动吸烟能引起大鼠肺泡壁增宽,间质、淋巴细胞浸润、肺泡腔内充满中性粒细胞和浓细胞,长期中等强度有氧运动具有修复和保护肺部的作用。

To study the influence of aerobic exercise about passive smoking rats growth performance and lung tissue ultrastructure and discuss the protection mechanism,this study conducted the experiment by selecting 322-month-age healthy male rats and dividing them into quiet group C,E,S,ES. It has intervened the aerobic exercise of ES and E rats for 8 days and the passive smoking of ES and S rats start from week 5 S,which dosed for eight / group / day. As a result,firstly,the weight of experimental group rats was a growing trend. Compared with C,the ES rats weight changed very significantly（ P 0. 01）. Compared with E,the S rats weight changed significantly（ P 0. 05）. Secondly,for lung and lung index,compared with the C,the S,E and ES rats lung and lung index changed significantly（ P 0. 05）. The ES and S rats appeared a lot of lung tissue inflammation,notably the S rat lung damage degree,while aerobic exercise intervention in the rat lung damage to a lesser degree.Thirdly,the E and C rats lung had a small amount of inflammation. The conclusions are as follows： First,passive smoking can slow up the body weight and lung tissue growth and aerobic exercise can stimulate lung growth and development. Furthermore,passive smoking can influence the rat alveolar walls broadening,interstitial,angiotelectasis and congestion. In order to the formation of the lymphocyte infiltration and lymphocyte follicular,alveolar lumen is filled with neutrophils and thick cells,moderate intensity aerobic exercise for a long time can repair and protect the lungs.