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椒目瓜蒌汤治疗恶性肿瘤胸腔积液临床研究 被引量:3

Clinical Study on Malignant Pleural Effusion Treated with Jiaomugualou Tang
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摘要 目的:观察椒目瓜蒌汤治疗恶性肿瘤胸腔积液的临床疗效。方法:选取62例恶性肿瘤胸腔积液患者,按照随机数字表法分为对照组30例与治疗组32例。对照组胸腔引流后给予顺铂、甘露聚糖肽、地塞米松、利多卡因注射液胸腔灌注,治疗组在对照组的基础上加用椒目瓜蒌汤。分析两组患者临床疗效、生存质量改善情况及不良反应发生情况。结果:治疗组临床疗效显著高于对照组,两组比较,差异有统计学意义(P<0.05);生存质量方面,对照组生存率为76.7%,治疗组生存率为93.7%,两组比较差异有统计学意义(P<0.05);两组患者胃肠道反应、头晕、发热、白细胞减少的发生率比较,对照组显著高于治疗组,两组比较,差异有统计学意义(P<0.05)。结论:西医常规胸腔灌注方法与中药椒目瓜蒌汤联用,可以提高临床治疗疗效,改善患者生存质量,减少不良反应的发生。 Objective : To observe the clinical curative effect of malignant pleural effusion treated with Jiaomugualou Tang. Methods : 62 cases of patients with malignant pleural effusion were divided into the control group (30 cases) and treatment group (32 cases) according to random number table. The control group given cisplatin was administered after chest drainage, mannan peptide, dexamethasone and lidocaine injection pleural perfusion. On the basis of the control group, treatment group was treated with Jiaomugnalou Tang. Compared two groups of clinical curative effect, life quality improvement and adverse reactions. Results : Clinical effect of the treatment group was significantly higher than that of the control group, the difference between the two groups had a statistical significance (P 〈 0.05 ). On the aspect of the quality of life, the survival rate of the control group was 76.7 % and 93.7 % of the treatment group. The difference between the two groups had a statistical significance ( P 〈 0. 05 ). Comparison of the occurrence rate of gastrointestinal tract reaction, dizziness, fever, white blood cell reduction in the two groups, the control group was significantly higher than that in the treatment group, the difference between the two groups had a statistical significance ( P 〈 0.05 ). Conclusion : The combination of western medicine routine intraperitoneal perfusion method and Jiaomugnalou Tang in Chinese medicine can improve the clinical curative effect, improve the patients quality of life, reduce the occurrence of adverse reactions.
作者 沈琴 祝玲
出处 《中医学报》 CAS 2016年第8期1089-1092,共4页 Acta Chinese Medicine
基金 湖北省自然科学基金项目(D2013CFB067)
关键词 椒目瓜蒌汤 恶性肿瘤 胸腔积液 中医药治疗 Jiaomugualou Tang malignant tumor pleural effusion TCM therapy
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