针刺联合补肾活血汤治疗排卵障碍性不孕临床研究

Clinical Study on the Treatment of Ovulation Dysfunction Infertility with Acupuncture Combined with Kidney Nourishing and Blood Activating Decoction

目的:观察针刺联合补肾活血汤治疗排卵障碍性不孕的临床疗效。方法:将门诊收集的排卵障碍性不孕患者60例随机分为治疗组和对照组,每组30例。治疗组给予口服补肾活血汤联合针刺治疗;对照组给予口服枸橼酸氯米芬联合绒毛膜促性腺激素(human choionic gonadotophin,HCG)治疗。治疗后观察两组的卵泡发育情况、排卵率、子宫内膜厚度、宫颈黏液评分、受孕率等指标。结果:1两组患者排卵率与妊娠率的比较,治疗组排卵59个周期,排卵率为65.56%,妊娠21例,妊娠率为70%;对照组排卵43个周期,排卵率为47.78%,妊娠11例,妊娠率为36.67%。两组比较,差异有统计学意义(P<0.05)。2两组患者宫颈黏液评分比较,治疗组59个排卵周期,宫颈黏液评分大于8分者个51个;对照组43个排卵周期,宫颈粘液评分大于8分者21个。两组比较,差异有统计学意义(P<0.05)。3两组患者临床疗效比较,治疗组有效8例,显效20例,无效2例,有效率为93.33%;对照组中有效13例,显效11例,无效6例,有效率为80.00%。两组比较,差异无统计学意义(P>0.05)。4两组患者子宫内膜厚度、最大卵泡直径比较,治疗组子宫内膜厚度为(11.24±0.51)mm;对照组子宫内膜厚度为(7.69±0.63)mm,差异有统计学意义(P<0.05)。治疗组最大卵泡直径为(21.16±1.58)mm;对照组最大卵泡直径(18.06±1.32)mm,差异有统计学意义(P<0.05)。结论:针刺联合补肾活血汤不仅可提高排卵率,还能通过增加子宫内膜厚度、改善宫颈黏液评分,提高受孕率。

Objective：To observe the clinical effect of acupuncture combined with kidney nourishing and blood activating decoction in the treatment of ovulation dysfunction infertility. Methods ： Collected in outpatient department of ovulatory disorder infertility patients 60 cases were randomly divided into treatment group and control group, 30 cases in each group. The treatment group was given kidney nourishing and blood activating decoction combined with acupuncture treatment and the control group was treated with oral folic acid chlorine clomiphene plus human chorionic gonadotropin （hCG）, intramuscular injection. After treatment observed two groups of follicles development, ovulation rate, endometrial thickness, the score of cervical mucus and pregnancy rate indicators. Results ： ①comparison two groups of patients with ovulation rate and pregnancy rate,59 cycles of treatment group ovulation, the ovulation rate was 65.56%, 21 cases of pregnancy, pregnancy rate was 70% ;43 cycles of control group ovulation, ovulation rate 47. 78% ,11 cases of pregnancy, pregnancy rate 36. 67%. The difference of the two groups was statistically significant （P 〈 0. 05 ）. ②Two groups of patients with cervical mucus scores compared showed that the treatment group 59 ovulation cycle, cervical mucus score greater than 8 points in 51 ,control group of 43 ovulation cycles,cervical mucus score greater than 8 in 21. Two groups compared with statistical significance （P 〈 0. 05 ）.③Comparison of the clinical efficacy of the two groups showed that the difference was statistically significant （ P 〈 0.05 ）. Namely, in treatment group ,8 cases were effective ,20 cases were markedly effective, 2 cases ineffective, the efficiency was 93.33% ; in the control group, 13 cases effective, 11 cases markedly effective, invalid in 6 cases,the effective rate was 80.00%. The two groups compared with. ④ompared the two groups of patients with endometrial thickness, diameter of the largest follicle showed that endometrial thickness of treatment group was （ 11.24 ± 0.51 ） mm, the control group（7.69 ±0.63 ） ram,the difference was statistically significant （ P 〈 0. 05 ）. The diameter of the largest follicle of treatment group was （ 21.16 ± 1.58 ） mm, the control group was （ 18.06 ± 1.32） ram, the difference was statistically significant （ P 〈 0.05 ）. Conclusion：Acupuncture combined with kidney nourishing and blood activating decoction can not only improve the ovulation rate, but also can increase the endometrial thickness,improve the cervical mucus score,improve the pregnancy rate.