苓桂术甘汤治疗变应性鼻炎临床研究

Clinical Research on Lingguizhugan Tang Treatment of Allergic Rhinitis

目的:观察苓桂术甘汤治疗变应性鼻炎的临床疗效及对血清炎症因子的影响。方法:将86例变应性鼻炎患者按随机数字表法分为观察组和对照组,每组43例。对照组43例给予西替利嗪治疗,观察组43例给予苓桂术甘汤治疗。观察两组患者治疗前后症状体征评分、血清炎症因子〔包括血清免疫球蛋白E(serum immunoglobulin E,lg E)、C反应蛋白(Creactionprotein,CRP)以及白细胞介素-4(Interleukin-4,IL-4)〕水平、不良反应情况和两组患者临床疗效。结果:治疗后两组患者的症状体征得分明显降低,且观察组的改变程度明显超过对照组,差异有统计学意义(P<0.05);两组治疗后血清炎症细胞因子Ig E、CRP以及IL-4水平较治疗前均明显降低,且观察组降低幅度明显大于对照组,差异有统计学意义(P<0.05);经治疗后观察组有效率为90.7%,对照组有效率为60.5%,两组比较,差异有统计学意义(P<0.05);观察组在治疗过程中出现不良反应3例,主要表现为腹痛、头晕;对照组出现不良反应11例,主要表现为局部红斑、瘙痒、恶心呕吐、腹痛腹泻、乏力等,两组不良反应比较,差异有统计学意义(P<0.05)。结论:苓桂术甘汤治疗变应性鼻炎临床疗效显著,能有效降低患者血清炎症因子水平,且不良反应较少。

Objective ：To observe the clinical curative effect observation of Lingguizhugan Tang in the treatment of allergic rhinitis and its influence on serum inflammatory factors. Methods：86 cases of allergic rhinitis patients were randomly divided into the ob- servation group and the control group,43 cases in each group. The control group was given cetirizine, and the observed group was treated with Lingguizhugan Tang. Observed symptoms and signs score, serum inflammatory factors,including serum immunoglobulin E （lgE）, C-reactive protein （CRP） interleukin-4 （IL-4） levels of the two groups before and after treatment and adverse reaction and clinical curative effect of the two groups. Results：After treatment, symptoms and signs scores of two groups of patients decreased significantly and the degree of change in the observation group significantly more than the control group; after treatmentinflammatory cytokine in serum IgE, CRP and the level of IL-4 in the two groups were significantly lower compared with before treatment, and the observation group decreased significantly than those of the control group, the difference was statistically significant （P 〈 0.05 ） ;after treatment, the effective rate of observation group was 90.7 % , and the control group was 60.5 %, the difference was statistically significant （P 〈 0.05 ） ; the observation group in the treatment of adverse reactions occurred in 3 cases, mainly manifested as abdominal pain, dizziness ; adverse reactions occurred in 11 cases of control group, mainly for local erythema, itching, nausea and vomiting, abdominal pain, diarrhea, fatigue, and so on, the two groups were compared, the difference was statistically significant （P 〈 0.05 ）. Conclusion：Lingguizhugan Tang in the treatment of allergic rhinitis has notable clinical curative effect, which can effectively reduce the level of serum inflammatory factors in patients, and less adverse reactions.