含噻唑环核N-硝基亚胺基咪唑烷类化合物的合成及生物活性研究

Synthesis and Biological Activity of N-(Imidazolidin-2-ylidene)nitramide Containing Thiazole Moiety

以氯噻啉为先导,利用类同合成方法,保留氯噻啉结构中噻唑环2-位氯原子,通过变换噻唑环4-位取代基,设计合成了8个氯噻啉类似物。所有化合物的结构均经~1H NMR、^(13)C NMR、质谱及元素分析等确认。初步生物活性测试结果表明:该类化合物具有一定的杀虫活性。在200μg/m L的浓度下,化合物8a和8g对桃蚜(Myzus persicae)致死率达70%。

Using imidaclothiz as the starting compound, eight imidaclothiz analogues were designed and synthesized according to the synthetic method of imidaclothiz where the chlorine atoms at 2-position was retained, and the d-position was introduced with different groups. The title compounds were characterized using 1H NMR, 13C NMR, MS and elemental analysis. Preliminary bioassay results showed that the target compounds had certain insecticidal activity. At a concentration of 200 μg/mL, compound 8a and 8g showed 90% larvicidal activity against Myzus persicae 200 mg/mL.