5-氨基酮戊酸光动力治疗寻常痤疮的疗效观察

Curative effect observation of 5-amino acid photodynamic therapy for acne vulgaris

目的观察5-氨基酮戊酸光动力疗法（ALA-PDT）治疗寻常痤疮的疗效。方法选取2015年1月~2016年6月我院治疗的痤疮患者60例,随机将其分为两组：一组左侧面部为试验侧,右侧面部为对照侧;另一组右侧面部为试验侧,左侧面部为对照侧。试验侧外敷3%ALA 1 h,红光照射20 min;对照侧只给予红光照射20 min。1次/周,疗程4周。每周观察疗效。结果治疗后试验侧粉刺（5.0±4.0）个、丘疹（2.7±2.2）个、脓疱（1.2±1.2）个、皮损计数（7.0±5.4）个,明显少于对照侧的（5.9±3.1）、（4.0±2.5）、（1.9±1.6）、（10.3±6.7）个,差异有统计学意义（均P〈0.05）。试验侧治疗第2周总有效率为61.7%,治疗第4周总有效率为78.3%,显著高于对照侧的21.7%、41.6%,差异有统计学意义（P〈0.05）。所有患者敷药过程中均无不适,9例患者在红光照射开始时出现局部灼热感,2例出现轻微疼痛感。结论 3%浓度ALA敷药1 h、光照20 min,4周1个疗程,是有效可行的治疗痤疮方案。

Objective To observe the effect of 5-amino acid photodynamic therapy（ALA-PDT） in the treatment of acne vulgaris.Methods 60 patients with acne treated in our hospital from January 2015 to June 2016 were selected and were randomly divided into two groups：a group of the left side of the face as the experimental side,the right side of the control side;the other group on the right side of the test side,the left side of the control side.The test side were given external 3% ALA 1 h,20 min red light irradiation;the control side only were given the red light irradiation 20 min.Once a week,4 weeks of treatment.The curative effect of every week was observed.Results After treatment,the acne was（5.0±4.0）,papules was（2.7±2.2）,pustules was（1.2±1.2）,lesion number was（7.0±5.4） in the test side,significantly less than that of the control side[（5.9±3.1）,（4.0±2.5）,（1.9±1.6）,（10.3±6.7）],the difference was statistically significant（all P〈0.05）.The effective rate of the test side was 61.7% in the second weeks,78.3% in the fourth weeks,which was significantly higher than that of the control side in 21.7% and 41.6% respectively,and the difference was statistically significant（P〈0.05）.All patients were treated in the process without discomfort,9 patients in the red light at the start of the local burning sensa tion,and 2 patients with mild pain.Conclusion The concentration of 3% ALA 1 h and 20 min treated light,4 weeks to1 course of treatment,is feasible and effective for the treatment of acne solutions.