艾塞那肽治疗肥胖型2型糖尿病的效果观察

The efficacy observavtion of exenatide therapy for patient with obesity type 2 diabetes mellitus

目的探讨艾塞那肽在口服降糖药最大有效治疗剂量无效的肥胖2型糖尿病中的疗效。方法回顾性分析2014年12月~2015年12月我院住院的40例患者的临床资料,按照数字随机表法将其分为两组,观察组采用艾塞那肽,对照组采用胰岛素强化治疗,观察治疗12周后空腹血糖（FBG）、餐后2 h血糖（2 h PG）、空腹C肽（FC-P）、糖化血红蛋（Hb A1c）水平。结果两组治疗后血糖、Hb A1c均下降（P〉0.05）。体重指数（BMI）水平观察组下降,对照组增加（P〈0.05）。两组HOMA-IR均下降,但观察组较对照组下降明显（P〈0.05）。观察组无低血糖事件发生。结论艾塞那肽能有效控制血糖,明显降低BMI,增加胰岛素敏感性。

Objective To explore the effect of exenatide in treatment of obesity type 2 diabetes mellitus patients whose blood glucose can not be controlled well by mximum dose.Methods The retrospective analysis of 40 cases of patients from December 2014 to December 2015 in our hospital were randomly divided into two groups according to digital random table method.Exenatide was used in the experimental group and insulin inth control group.The changes in the levels of fasting blood glucose,two-hour postprandial blood glucose,fasting C-peptide and hemoglobin A1c（Hb A1c） were observed at the twelve weeks.Results The blood glucose and Hb A1 c of the two groups decreased at the twelve weeks（P〈0.05）.BMI decreased in the experimental group and increased in the control group（P〈0.05）.The HOMA-IR of the two groups decreased and was more obvious in the experimental group than that in the control group（P〈0.05）.No hypoglycemia happened in the experimental group.Conclusion Exenatide can reduce blood glucose and body weight efficiently.And it can improve the sensitivity of insulin at the same time.