中性粒细胞碱性磷酸酶阳性积分、降钙素原与细菌感染类型的相关性分析

目的探讨中性粒细胞碱性磷酸酶（NAP）阳 性积分及降钙素原在革兰氏阳性（G＋）球菌感染 的诊断意义.方法应用快速偶氮偶联法分别对我科收治的 65例感染患者NAP阳性积分和降钙素原（PCT）检测,对比革兰氏阳性（G＋）球菌感染、革兰氏阴性（G-）杆菌感染时 NAP阳性积分和PCT 值的差异.结果革兰氏阳性球菌感染患者的NAP阳性积分显著高于革兰氏阴性杆菌感染患者（P〈0.05）;NAP阳性积分的ROC曲线下面积 =0.662,敏感度=0.615,特异度=0.718.革兰氏阳性球菌感染和革兰氏阴性杆菌感染组PCT值比较,差异无统计学意义（P〉0.05）.结论NAP阳性积分可以作为判断革兰氏阳性球菌感染的参考依据.

ObjectiveTo explore the clinical value of analyzing neutrophil alkaline phosphatase （NAP） activity and calcitonin original on G＋ bacteria infection indentification. Methods65 infected patients’ NAP positive score and calcitonin original were measured in ICU. The two index of different patients were recorded and compared to each other. ResultsThe NAP positive score in G＋ infection patients is significantly higher than G- infection patients （P〈0.05） . The area under the ROC curve of The NAP positive score is 0.662, the sensitivity is 0.615 and specific degree is 0.615. But there is no significant different in PCT between G- infection patients （P〉0.05）. ConclusionNAP positive score can be used as a tool for G＋ bacteria infection identification, used with the PCT can improve the diagnosis of G＋ bacteria infection.