芳香新塔花茶对小鼠镇静催眠、生长发育及免疫器官指数的影响研究

Effects of the Ziziphora clinopodioides Lam Tea on Sedative-hypnotic,Immune Organ Index,Growth and Development of Mice

目的:研究芳香新塔花茶对小鼠的镇静催眠、生长发育及免疫器官指数的影响.方法:用不同剂量的芳香新塔花茶灌胃,用自发活动记录法记录60 min内小鼠自发活动次数,利用阈剂量戊巴比妥钠睡眠实验法和阈下剂量戊巴比妥钠诱导小鼠睡眠实验,观察芳香新塔花茶镇静催眠作用.用称重法,观察法及计量法研究芳香新塔花茶对小鼠生长发育及免疫器官指数的影响.结果:芳香新塔花茶低、中、高剂量组对小鼠走动次数、举双前肢数、入睡时间、体重,免疫器官指数作用差异显著(p<0.05)或差异极显著(p<0.01),且呈剂量依赖效应;给药组小鼠的生长发育状况更加良好.结论:芳香新塔花茶具有显著的镇静催眠、促进生长发育及免疫增强作用.

Objective To study the effects of different doses of the tea from Ziziphora clinopodioides Lam on sedative- hypnotic, immune function, growth and development of mice. Methods： Compared with the physiological saline groups, the effects of the Ziziphora clinopodioides Lam tea on spontaneous activity of mice, dormancy-number and dormancy-time of mice induced by pentobarbital sodium were observed, and the spleen index, thymus index, liver index, growth and development with three doses of Ziziphora clinopodioides Lam tea were determined. Results ： Compared with the physiological saline groups, the three doses of the Ziziphora clinopodioides Lam tea could inhibit the spontaneous activity, increase dormancy- number and dormancy-time of mice induced by pentobarbital sodium, and it could also obviously increase the spleen index, thymus index, liver index and strengthen the growth and development of mice. Conclusions： The Ziziphora clinopodioides Lam tea has obviously sedative and hypnotic effects in mice and there is a synergistic effect between them and pentobarbital sodium, and the tea could also obviously strengthen the immune function, growth and development of mice.