GnRHa对卵巢癌术后辅助化疗患者卵巢的保护作用的研究

The research of Protective effect on ovarian function in postoperative assistant chemotherapy patients with ovarian cancer using GnRHa

目的:本研究通过对年轻卵巢癌患者术后化疗时应用亮丙瑞林治疗,探讨亮丙瑞林对卵巢功能的保护作用。方法:收集2010年1月至2013年3月收治的17例年轻卵巢癌患者的临床资料,根据患者是否同意化疗同时使用亮丙瑞林分成治疗组及对照组,分别测定两组患者化疗前、化疗期间、化疗后血清中雌二醇(E2)、卵泡刺激素(FSH)的水平,观察两组患者月经情况及化疗后妊娠生育情况。数据分析采用SPSS 13.0统计学软件处理,以P<0.05为差异有统计学意义。结果:治疗组患者在应用亮丙瑞林后化疗期间均闭经;E2水平减低,FSH也明显降低;治疗结束后全部恢复正常月经周期;对照组在化疗期间出现月经周期紊乱,E2水平逐渐降低,FSH则明显增加,治疗结束后仅半数恢复月经周期。结论:保留生育功能的卵巢癌患者化疗时提前应用亮丙瑞林,能够在化疗过程中减少化疗药物对卵巢功能的损伤,对卵巢内分泌功能及生育功能均有保护作用。

Obj ective：To study Protective effect of leuprorelin on ovarian function in young patients with ovarian cancer suffer chemotherapy after surgery.Methods：To collect clinical data of 17 young patients with ovarian cancer during January 2010 to March 2013,The cases were divided into treatment group and control group according to whether using leuprorelin .the ser-um estradiol （E2 ）,follicle-stimulating hormone （FSH ）levels were detected Before chemotherapy,during chemotherapy and after chemotherapy .The situation of menstruation and Pregnancy were observed.Results：During chemotherapy abnormal menstrual cycle ,E2 levels decreased were occurred in two group.the FSH level was significantly reduced in treatment group and significantly decreased in treatment group and significantly increased in control group;After chemotherapy the menstrual cycles of all cases were recoved in treatment group,In Control group Only half of all cases.Conclusion：In postoperative assis-tant chemotherapy patients with ovarian cancer leuprorelin may have Protective effect on ovarian function.