局部晚期宫颈癌新辅助化疗和放疗联合治疗

Combination treatment of neoadjuvant chemotherapy with radiation for locally advanced cervical cancer

铂类为基础的同步放化疗在美国国立综合癌症网络(NCCN)指南中被认为是局部晚期宫颈癌的标准治疗方案,而在欧洲、日本、韩国以及拉丁美洲,局部晚期宫颈癌的其他治疗方式被认为具有同样的治疗效果。目前我国医疗机构水平参差不齐,放疗设备不一,新辅助化疗(NACT)联合放疗或同步放化疗不失为一种可选择的方法。不可忽视手术在局部晚期宫颈癌中的作用,新辅助化疗仅是局部晚期宫颈癌综合治疗措施中的一部分,临床应用需谨慎,不可滥用,不能将NACT作为单一的、主要的治疗手段。

Abstract： Platinum-based concurrent chemoradio- therapy in the NCCN guidelines is considered as a standard treatment for locally advanced cervical car- cinoma. Nevertheless, other treatment modalities with similar efficacy have been developed in such regions Europe, Japan, South Korea, and Latin America. Because of the different levels of medical institutions and radiotherapy equipment in China, neoadjuvant themotherapy combined with radiotherapy or chemoradiation can yet be regarded as an alternative method. The role of surgery can＇ t be ignored in the treatment of locally advanced cervical cancer, and neoadjuvant chemotherapy is only one part of the comprehensive treatment for locally advanced cervical cancer, so clinical applications should be careful. NACT can＇ t be regarded as a single and primary treatment.