局部晚期宫颈癌术前动静脉化疗利弊

The advantage and disadvantage of intra-arterial and intravenous neoadjuvant chemotherapy for locally advanced cervical cancer

根据我国国情,局部晚期宫颈癌术前新辅助化疗的实施有存在的必要,但是化疗方式的选择却存在较大的争议。术前静脉化疗仅仅是在近10年来由于新的有效的抗癌药物的出现而占尽了优势,但是宫颈癌动脉化疗的历史较静脉化疗更为悠久,动脉化疗能在较短时间之内通过提高癌灶内的药物剂量而有效缩小肿瘤体积,为后续治疗奠定手术基础。文章就两种化疗方式的利弊问题,从动脉化疗的历史、机制、与静脉化疗的疗效对比、经济效益比较等方面进行讨论,供临床医生参考。

The performance of neoadjuvant ehemotherapy for treating locally advanced cervical cancer was still needed to exist according to our country.But it was controversy about the approach of chemotherapy. The history of intra-arterial chemotherapy was hmger than intravenous chemotherapy which only developed in the last decade due to the emergence of new effective anticancer drugs.Intraarterial chemotherapy can in- crease the drugs＂ dosage in a short time and reduce tumor volume effectively.That was the foundation for the subsequent surgical treatment.This article was aided to understand the advantages and disadvantages of two neoadjuvant chemotherapy＇s approach through discussing the history, mechanism, efficacy and economic benefits.