儿童铜绿假单胞菌脓毒症14例临床分析

Clinical analysis of 14 cases of Pseudomonas aeruginosa sepsis in children

目的了解儿童铜绿假单胞菌脓毒症的临床特点及药敏情况。方法回顾性分析2006-2016年诊断为铜绿假单胞菌脓毒症患儿的临床资料。结果符合铜绿假单胞菌脓毒症诊断患儿共14例,多于婴幼儿发病(78.6%),常见并发症为弥漫性血管内凝血(DIC)、肺出血。14例患儿中,7例治愈、4例死亡、3例因病情重家属放弃治疗。药敏结果提示所分离铜绿假单胞菌对氨基糖苷类和喹诺酮类抗生素具有良好的敏感性。结论铜绿假单胞菌脓毒症以婴幼儿多见,病死率高。对于疑诊患儿,早期抗感染治疗应使用覆盖铜绿假单胞菌的抗生素。

Objective To summarize the clinical characteristics and drug sensitivity of Pseudomonas aeruginosa in children. Methods The data of children with diagnosed Pseudomonas aeruginosa from 2006 to 2016 were retrospectively analysis. Results There were 14 patients who had diagnosis of Pseudomonas aeruginosa, most of whom were infants and toddlers（ 78. 6 %）. The common complications were disseminated intravascular coagulation（DIC） and pulmonary hemorrhage. In 14 patients, 7 patients were cured, 4 were died, and 3 were given up treatment by their family because of serious illness. The antimicrobial susceptibility test showed that isolated pseudomonas aeruginosa had good sensitivity to aminoglycosides and quinolones. Conclusion Pseudomonas aeruginosa sepsis is more common in infants and toddlers, with high mortality. For suspected patients, the antibiotic that covers the Pseudomonas aeruginosa should be used in early antibiotic therapy.