地西他滨联合半程和全程CAG方案治疗骨髓增生异常综合征和急性髓系白血病的效果比较

Effect comparison of Decitabine combined with half and full course of CAG regimen in the treatment of myelodysplastic syndrome and acute myeloid leukemia

目的 分析地西他滨联合半程和全程CAG方案治疗骨髓增生异常综合征（MDS）和急性髓系白血病（AML）的效果差异。方法 回顾性分析2012年10月~2013年10月乐山市人民医院肿瘤血液科收治的MDS和AML患者的临床资料,将所有患者分为观察组和对照组,对照组患者接受地西他滨联合半程CAG方案治疗,观察组患者接受地西他滨联合全程CAG方案治疗,对比两组患者的治疗效果、毒副作用、生存相关指标等的差异。结果治疗后,观察组治疗后缓解率及总反应率均高于对照组（P〈0.05）;观察组治疗过程中肺部感染、脑出血、严重骨髓抑制、严重中性粒细胞减少以及血小板减少事件发生率均显著低于对照组（P〈0.05）;观察组治疗后中位疗程数显著少于对照组,中位总生存时间显著长于对照组,1年生存率、2年生存率均显著高于对照组,差异均有统计学意义（P〈0.05）。结论 地西他滨联合全程CAG方案治疗MDS和AML可以更为有效地提升治疗效果,延长患者生存时间,同时不增加患者的毒副作用发生率。

Objective To analyze the difference of the effect of Decitabine combined uith half and full course of CAG regimen in the treatment of myelodysplastic syndrome （MDS） and acute myeloid leukemia （AML）. Methods The clinical data of patients with MDS and AML admitted to Department of Tumor and Hematology, the People＇s Hospital of Leshan City from October 2012 to October 2013 was analyzed retrospectively, all patients were divided into control group and observation group, the control group received Decitabine combined with half course of CAG regimen, the observation group received Decitabine combined with full course of CAG regimen. The differences of curative effect, side effects, survival related indicators of the two groups were compared. Results After treatment, the remission rate and overall response rate of observation group were significantly higher than those of control group （P 〈 0.05）; the incidence of lung infection, brain hemorrhage, severe bone marrow suppression, severe neutropenia and thrombocytopenia during treatment in the observation group were all significantly lower than those .of control group （P 〈 0.05）; the number of median treatment course of observation group was less than that of control group, the median overall survival time was longer than that of control group, the 1-year survival rate and 2-year survival rate were all higher than those of control group, the differences were all statistically significant （P 〈 0.05）. Conclusion Decitabine combined with full course of CAG regimen in the treatment of MDS and AML can more effectively improve the therapeutic effect and prolong the survival time, without increasing the incidence of side effects.