梗阻性无精子症患者术后应用麒麟丸疗效观察

Qilin Pills for obstructive azoospermia after ejaculatory duct reconstruction

目的：观察梗阻性无精子症患者接受精道显微重建手术后应用麒麟丸后的临床疗效。方法：回顾性分析75例因梗阻性无精子症行精道重建成功者采用麒麟丸治疗后精子质量的改变情况。将75例精道重建成功的重度少精子症患者随机分为两组，即治疗组（42例）与对照组（33例），其中治疗组给予麒麟丸治疗，对照组给予安慰剂治疗。治疗3个月后，观察两组精子质量改变情况。结果：两组患者均完成了3个月的治疗。两组治疗后，精液质量均有明显提高。其中，麒麟丸组和对照组精子浓度分别从（0．57±0．25）×10^6／nd和（0．60±0．18）×10^6／ml提高到（2．83±0．59）×10^6／ml和（1．72±0．52）×10^6／ml，麒麟丸组比对照组改善更明显（P〈0．05）；a级精子百分率分别从（5．52±5．97）％和（5．30±6．26）％提高到（11．56±9．96）％和（10．27±6．52）％，a＋b级精子百分率分别从（9．68±8．63）％和（8．64±10．10）％提高到（23．42±14．10）％和（20．81±14．70）％，正常形态精子百分率分别从（2．00±1．27）％和（2．31±0．94）％提高到（3．54±2．47）％和（3．47±1．33）％，两组治疗后精子活力和正常形态精子百分率均没有统计学差异（P〉0．05）。麒麟丸组和对照组总有效率分别为88．1％和72．7％，差异亦没有统计学意义（P〉0．05）。结论：对于精道重建成功的梗阻性无精子症患者，应用麒麟丸对提高精子数量有一定疗效。

Objective ： To observe the clinical effect of Qilin Pills in the treatment of severe oligozoospermia after microsurgical ejaculatory duct reconstruction for obstructive azoospermia. Methods ： We retrospectively analyzed 75 cases of obstructive azoospermia treated by ejaculatory duct reconstruction followed by administration of Qilin Pills. The paiients were divided into a Qilin group （ n = 42 ） and a control group （ n = 33 ） postoperatively, treated with Qilin Pills and placebo, respectively. After 3 months of medication, we compared the sperm quality between the two groups of patients. Results ： After 3 months＇treatment, all the patients experienced re- markable improvement in sperm quality （P 〈 0.05）. Compared with the controls, the patients in the Qilin group showed dramatic in- creases in sperm concentration, from （0.57 ±0.25） and （0.60 ±0.18） ×10^6/ml before medication to （2.83 ±0.59） and （ 1.72 ± 0.52） × 10^6/ml after medication, significantly higher in the Qilin than in the control group （P 〈 0.05 ）. The percentage of grade a sperm was increased from （ 5.52 ± 5.97 ） and （5.30 ± 6.26） % to （ 11.56 ± 9.96） and （ 10.27 ± 6.52 ） % , that of grade a ± b sperm from （ 9.68 ± 8.63 ） and （ 8.64±10.10 ） % to （ 23.42 ± 14.10 ） and （ 20.81 ± 14.70 ） % , and that of morphologically normal sperm from （2.00 ± 1.27） and （2.31± 0.94） % to （3.54 ± 2.47） and （ 3.47 ± 1.33 ） % , respectively. No statistically significant differ- ences were observed in sperm motility and normal sperm morphology between the two groups after treatment （ P 〉 0.05 ）. The totaleffectiveness rate was higher in the Qilin group than in the controls （88.1% vs 72.7% ） , but with no significant difference between the two groups （ P 〉 0. 05 ）. Conclusion ： Qilin Pills are fairly effective in improving the quantity of sperm in obstructive azoospermia pa- tients ＇after ejaculatory duct reconstruction.