β2肾上腺素能受体信号通路在肝细胞癌发生发展中的作用

Role of β2 adrenergic receptor signaling pathway in hepatocellular carcinoma

肝细胞癌(hepatocellular carcinoma,HCC)因发病隐匿、预后极差而严重影响患者生存期,是常见的恶性肿瘤之一.研究发现β肾上腺素能受体信号通路与多种肿瘤的发生和发展密切相关,尤其以β2肾上腺素能受体(β2-adrenergic receptor,β2-AR)信号通路为主参与的肿瘤细胞的分化、增殖和凋亡,参与肿瘤的血管生成、肿瘤的生长和转移.本综述拟探讨β2-AR信号通路在HCC发生与发展的调控机制,为进一步开展HCC相关的发病机制、诊断、治疗方面的研究提供新思路和方法.

Hepatocellular carcinoma（HCC） is one of the most common malignancies characterized by insidious onset and poor prognosis.Studies have shown that β adrenergic receptor signaling,especially β2 adrenergic receptor（β2-AR） signaling,regulates multiple cellular processes that contribute to the initiation and progression of cancer,including differentiation,proliferation and apoptosis.β2-AR signaling is also involved in tumor angiogenesis,progression and metastasis in HCC.Therefore,understanding of the role of the β2 adrenergic receptor signaling pathway in HCC progression and metastasis will be of great value in developing therapeutic strategies for this maliganancy.In this paper,we will discuss the role of β2 adrenergic receptor signaling pathway in HCC.