摘要
目的探讨白芍总苷片与糖皮质激素联合治疗系统性红斑狼疮肝损害的临床疗效,为提高该病治疗效果提供参考.方法收集医院2013-06/2015-06 92例系统性红斑狼疮肝损害患者作为研究对象,依据随机对照组表法分为联合组与对照组,各46例.对照组给予常规糖皮质激素治疗,联合组给予白芍总苷片与糖皮质激素联合治疗,观察两组患者治疗总有效率、肝功能改善状况以及不良反应.结果联合组总有效率高于对照组(93.5%v s73.9%),差异有统计学意义(P<0.05).治疗后联合组ALT、γ-GT、AST均明显的低于对照组,(31.7±7.4 vs 62.4±10.5)、(21.7±4.8 vs35.7±5.8)、(88.4±9.1 vs 121.6±10.7),组间差异有统计学意义(P<0.05).联合组治疗不良反应发生率明显的低于对照组(8.7%vs23.9%),差异有统计学意义(P<0.05).结论系统性红斑狼疮肝损害患者在常规糖皮质激素治疗上加用白芍总苷片治疗效果明显,显著改善患者肝功能,且不良反应少,安全性高,值得应用推广.
AIM To evaluate the clinical effects of oral prednisone acetate combined with total glucosides of peony(TGP) for treatment of liver injury associated with systemic lupus erythematosus.METHODS Ninety-two systemic lupus erythematosus patients with liver injury treated at our hospital from June 2013 to June 2015 were included and randomly divided into either a study group or a control group,with 46 cases in each group.The control group received conventional prednisone acetate therapy,and the study group received TGP and prednisone acetate.The efficacy,liver function status and adverse reactions were compared between the two groups.RESULTS The total effective rate was significantly higher in the study group than in the control group(93.5%vs 73.9%,P 〈 0.05).After treatment,serum ALT,γ-GT and AST were significantly lower in the study group than in the control group(31.7 ± 7.4 vs 62.4 ± 10.5;21.7 ± 4.8 vs 35.7± 5.8;88.4 ± 9.1 vs 121.6 ± 10.7,P 〈 0.05).The incidence of adverse events was significantly lower in the study group than in the control group(8.7%vs 23.9%,P 〈 0.05).CONCLUSION Compared with conventional glucocorticoid therapy,oral prednisone acetate combined with TGP has better curative effect,can significantly improve liver function and is associated with fewer adverse reactions in patients with liver injury associated with systemic lupus erythematosus.
出处
《世界华人消化杂志》
CAS
2016年第24期3618-3621,共4页
World Chinese Journal of Digestology
关键词
系统性红斑狼疮
肝损害
糖皮质激素
白芍总苷片
疗效
Systemic lupus erythematosus
Liver injury
Glucocorticoids
Total glucosides of peony
Efficacy