核因子κB信号转导通路与子宫内膜异位症

Nuclear Factor-κB Pathway and Endometriosis

子宫内膜异位症是妇科常见病,疑难病。虽为良性疾病,却有侵袭、转移等恶性生物学行为。核因子κB(NF-κB)信号转导通路参与了炎症、细胞生存、增殖、凋亡以及免疫反应等病理过程。NF-κB信号通路在子宫内膜异位症中被过度激活,通过调节下游因子的表达,影响性激素的表达,促进炎症反应及氧化应激,减少凋亡,增加异位内膜的黏附、侵袭及血管生成能力,与子宫内膜异位症的发生、发展关系密切。

Endometriosis is a common gynecological incurable disease. Although it is benign, it has malignant behaviors such as invasion and metastasis. Nuclear factor-KB （NF-KB） signal transduction pathway is involved in inflammation, cell survival, proliferation and apoptosis, pathological immune response. NF-KB signaling pathway is over-activated in endometriosis, which can influence the expression of sex hormones, pro- mote inflammation and oxidative stress, reduce apoptosis, and increase adhesion, invasion, angiogenesis ability of ectopic endometrial by regulating the expression of downstream factors. NF-KB signal pathway is closely related to the occurrence and development of endometriosis.