摘要
目的 系统评价人类着色性干皮病D组(XPD)基因多态性Lys751GIn及Asp312Asn与肺癌的关联。方法 检索中英文数据库查找涉及ERCC2/XPD基因多态性Lys751Gln及Asp312Asn与肺癌易患性关系的病例对照研究,提取数据进行Meta分析。选用比值比(OR)和95%置信区间(95%CI)作为合并效应量。结果 共32篇纳入研究,累计病例组肺癌人数为19 542例,对照组非肺癌人数为25 078例。312Asn/Asn、751Gln/Gln及751Lys/Gln基因型携带者肺癌易患性明显升高(Asn/Asn比Asp/Asp:OR=1.140(95%CI 1.014~1.281),P=0.028;Gln/Gln比Lys/Lys:OR=1.294(95%CI 1.154~1.451),P〈0.001;Lys/Gln比Lys/Lys:OR=1.149(95%CI 1.064~1.241),P〈0.001)。结论 ERCC2/XPD基因的单核苷酸多态性Asp312Asn和Lys751Gln作为肺癌发病的危险因素与肺癌易患性相关。
Objective To systematically evaluate the association of the xerodermapigmentosum comple-mentary group D (XPD) Lys751GIn and Asp312Asn polymorphism with risk of lung cancer. Methods Case control study about the association between ERCC2/XPD Lys751Gln and Asp312Asn and lung cancer was screened out from both English and Chinese databases to conduct a meta-analysis. The pooled OR and 95 % CI were calculated as effect sizes. Results Altogether 32 publications were included ( 19 542 cases and 25 078 controls). C, enotype 312Asn/Asn,751Gln/Gln and 751Lys/Gln increased lung cancer susceptibility [ Asn/Asn vs Asp/Asp: OR = 1. 140 (95 % CI 1. 014-1. 281 ), P = 0. 028 ; Gln/Gln vs Lys/Lys : OR = 1. 294 (95% CI 1. 154-1. 451 ), P 〈 0. 001 ; Lys/Gln vs Lys/Lys: OR = 1. 149 ( 95% CI 1. 064-1. 241 ), P 〈 0. 001 ]. Conclusion ERCC2/XPD Asp312Asn and Lys751Gln are connected with lung cancer susceptibility as independent risk factors.
出处
《医学综述》
2016年第18期3663-3669,共7页
Medical Recapitulate