激光粒度仪测定非诺贝特粒度分布的应用研究

Application of laser particle size analyzer in fenofibrate particle size distribution measurement

目的建立激光粒度仪测定非水溶性的非诺贝特晶体粒度分布的实验方法。方法本文采用英国马尔文公司的Mastersizer 3000激光粒度仪系统研究了样品折射率、分散介质、分散剂种类及分散剂质量浓度、遮光度、浆液循环泵转速、超声强度及时间对非诺贝特粒度分布测量结果的影响。结果实验结果表明,非诺贝特产品在水中易团聚,必须添加适当的分散剂并辅以适当的超声波来促进粒子在水中的均匀分散。Mastersizer 3000激光粒度仪测定非诺贝特晶体粒度的最佳条件为:样品折射率选取1.55,分散剂洗洁精浓度为0.0025g/m L,遮光度为10%,浆液循环泵转速2000r/min,超声强度20W,超声分散40s。结论该实验方法快速、简便、重现性好、精度高,可用于非诺贝特粒度分布的测定。

Objective To establish an experimental method for the measurement of the particle size distribution of water-insoluble fenofibrate by using laser particle size analyzer. Methods In this paper, the influences of refractive index of the sample, dispersion medium, dispersants type, dispersants＇ concentration, shading degree, the speed of slurry circulating pump, ultrasonic intensity and ultrasonic dispersing time on the measurement result of the particle size distribution of fenofibrate were systematically studied by using Malvern Mastersizer 3000 laser particle size analyzer. Results Experimental results showed that fenofibrate products were easy to agglomerate in the water, and must be added to an appropriate dispersant and auxiliary appropriate ultrasonic to promote the particles to disperse evenly in the water. The optimum conditions for the experiments were as follows： refractive index of the sample was 1.55, detergent dispersant＇ concentration was 0.0025g/mL, shading degree was 10%, the revolving speed of slurry circulating pump was 2000r/min, ultrasonic intensity was 20W and ultrasonic dispersing time was 40s. Conclusion The said measuring method was quick, easy, and of good repeatability and high precision, and it could be used for the measurement of the particle size distribution of fenofibrate.