亚低温治疗对心跳骤停复苏成功后并发癫痫患者预后的影响

Effect of mild hypothermia therapy on the prognosis of patients with epilepsy complicated by cardiac arrest after successful resuscitation

目的：探讨亚低温治疗对心跳骤停复苏成功后并发癫痫患者预后的影响。方法：回顾性分析我院79例于2013-12-2015-12进行心脏骤停复苏成功后并发癫痫患者。将患者分为实验组和对照组,其中实验组39例,对照组40例,选取实验组患者均进行亚低温治疗,对照组患者进行常规治疗,并在治疗过程中使用脑电图监测。记录患者病历中本研究所需数据,分析使用亚低温治疗对患者预后的影响。结果：在治疗过程中,共有40例患者发生了癫痫,实验组发生癫痫的患者有14例,对照组发生癫痫的患者有26例,对照组的癫痫发生率显著高于实验组（χ~2=6.69,P〈0.05）。实验组和对照组患者在心肺复苏后和治疗中的癫痫发生率差异均无统计学意义,在治疗后癫痫的发生率差异有统计学意义（χ~2=5.23,P〈0.05）;进行治疗的患者58例死亡,其中并发癫痫患者40例全部死亡;院内治疗过程中死亡的患者有42例,其中有并发癫痫患者27例;出院后在心跳骤停28d内死亡的患者有16例,其中有并发癫痫患者13例。未发癫痫患者在心跳骤停28d内死亡的有18例,病死率为46%,并发癫痫患者病死率为100%,显著高于未发癫痫患者（χ~2=29.34,P〈0.05）。结论：亚低温治疗能降低心跳骤停复苏成功后患者的癫痫发生率,但对心跳骤停复苏成功后并发癫痫患者的预后情况较差。

Objective：Discuss the effect of mild hypothermia therapy on the prognosis of patients with epilepsy complicated by cardiac arrest after successful resuscitation.Method：Using retrospective study,we selected 79 cases of patients with epilepsy after cardiac arrest and resuscitation in December 2013~2015,December.Patients were divided into the experimental group and the control group.The patients in the experimental group 39 cases,control group of 40 patients,selected patients in the experimental group were mild hypothermia therapy,the patients of control group were treated with conventional therapy,and the use of EEG monitoring in the course of treatment.The data of the patients were recorded,and the effect of mild hypothermia treatment on the prognosis of the patients was analyzed.Result：In the course of treatment,a total of 40 cases occurred in patients with epilepsy,the experimental group occurred epilepsy patients in 14 cases,occurred in the control group and patients with epilepsy in26 patients.In the control group,the incidence of epilepsy was significantly higher than that in the experimental group（χ~2=6.69,P〈0.05）.The experimental group and the control group in patients after cardiopulmonary resuscitation,the incidence of epilepsy was not statistically significant difference,the experimental group and the control group in the treatment of epilepsy in patients with the incidence rate of the difference was not statistically significant,the experimental group and the control group in the treatment of patients with epilepsy have differences in incidence statistical significance（χ~2=5.23,P〈0.05）;for the treatment of patients with 58 cases of death,including 40 cases of patients with epilepsy died,died in hospital in the course of treatment in 42 patients,of which 27 cases of patients with epilepsy,died after leaving hospital cardiac arrest in 28 din 16patients,of which 13 cases of patients with epilepsy.There were 18 cases of death in patients with cardiac arrest in 28 d,the mortality was 46%,and the mortality rate was 100%,which was significantly higher than that of the patients without epilepsy（χ~2=29.34,P〈0.05）.Conclusion：Mild hypothermia therapy can reduce the incidence of epilepsy after cardiac arrest resuscitation,but the prognosis of patients with epilepsy after successful resuscitation is poor.