血管紧张素Ⅱ对血管平滑肌细胞CRP表达的影响

Effect of angiotensin Ⅱ on CRP expression of vascular smooth muscle cells

动脉粥样硬化是血管壁的炎症性疾病。C反应蛋白(CRP)作为急性时相反应蛋白,不仅是一个非特异性炎症标志物,它还能影响血管平滑肌细胞的迁移和增生,参与动脉粥样硬化的发生、发展过程。血管紧张素Ⅱ作为肾素血管紧张素系统(RAS)最重要的成分是一个致炎细胞因子,可活化血管平滑肌细胞并诱导多种炎性细胞因子的释放,因此CRP和RAS之间可能存在相关性。

Atherosclerosis is an inflammatory disease of the blood vessel wall.C-reactive protein as an acute phase protein,is a non-specific inflammatory marker,which not only affect vascular smooth muscle cells migration and proliferation,but also participates in the occurrence and development of atherosclerosis.AngiotensinⅡas the most important component of the renin-angiotensin system（RAS）is a proinflammatory cytokine,which can activate a variety of vascular smooth muscle cells and induce the release of inflammatory cytokines,so there may be a correlation between CRP and RAS.