血清C-反应蛋白及同型半胱氨酸水平与冠心病PCI预后的相关性研究

Correlation studies among C-reactive protein,serum homocysteine level and prognosis in coronary heart disease patients after intervention treatment

目的:评价血清超敏C-反应蛋白(hs-CRP)及同型半胱氨酸(Hcy)水平对冠心病患者经皮冠状动脉介入治疗(PCI)预后的影响。方法:将158例冠心病PCI患者根据Hcy水平分为2组,组内再根据hs-CRP水平分为2个亚组,随访24个月,观察主要心血管事件发生率。结果:随访6个月发现,除靶血管再狭窄率在不同hsCRP水平间无明显差异外,各组之间MACE发生率的差异均有统计学意义(均P<0.05)。术后24个月Hcy升高组与Hcy正常组之间、hs-CRP升高组与hs-CRP正常组之间MACE事件发生率均有显著差异(均P<0.05)。多变量分析表明,对MACE有独立预测价值的因素包括hs-CRP及Hcy水平。结论:对Hcy及hs-CRP升高的患者,应积极进行干预,以减少冠心病PCI后心血管事件的发生。

Objective：Evaluation of serum C-reactive protein（hs-CRP）and homocysteine（Hcy）level on predicting the prognosis of coronary heart disease interventional therapy.Method：One hundred and fifty-eight cases of coronary heart disease patients with interventional therapy were divided into 2groups according to the serum Hcy level seach of which was further divided into two subgroups according to hs-CRP level.All patients were followed up for 24 months to receive the observation of the incidence of major cardiovascular events.Result：The target vascular restenosis rate had no obvious difference among all the groups.However,the incidence of major adverse cardiovascular events（MACE）was significantly different between each group.Twenty-four months after interventional therapy,the incidence of MACE were significantly different between the normal group and the group with increased hs-CRP（P〈0.05）.Multivariate analysis showed that the independent predictive value for MACE factors includeed hs-CRP and serum Hcy levels.Conclusion：Patients with elevated serum Hcy and high-sensitivity hsCRP should receive active intervention to reduce MACE after coronary interventional treatment.