添加双歧杆菌的肠内营养对重症脑卒中病人肠道菌群的影响

Additionalbifidobacteria in severe stroke patients receiving enteral nutrition

目的:探讨肠内营养(EN)添加双歧杆菌辅助治疗对重症脑卒中病人肠道菌群的影响。方法:选择入住我科的重症脑卒中病人124例,随机分为治疗组和对照组,每组各62例。对照组给予常规EN治疗,治疗组在对照组治疗的基础上加用双歧杆菌治疗,两组治疗观察14 d。结果:治疗后,治疗组病人肠道有益菌群(乳酸杆菌、双歧杆菌、拟杆菌、真杆菌、消化球菌等)数量明显高于对照组,而肠道致病菌群(大肠杆菌、肠球菌和小梭菌等)数量明显少于对照组(P<0.05)。结论:EN液中添加双歧杆菌辅助治疗重症脑卒中病人能有效地调节肠道菌群失调,促进病人康复。

Objective： To investigate the effect of enteral nutrition （EN） with additionalbi- fidobacteria on intestinal flora insevere stroke patients. Methods： 124 cases of severe stroke patients admitted to our department were randomly divided into the control group and the experimental group, while 62 cases in each group. The control group was given conventional EN support, andthe experimental group was treated the EN therapy, which was the same as thecontrol groupwith additional Bifidobacterium. After 14 days stool culturewerecollectedto analysis the intestinal flora. Results： Compared with the control group, theintestinal beneficial bacteria in the experimental group of patients （Lactobacillus, Bifidobacterium, Baeteroides, Eubacterium and peptococcus） was significantly enhanced （ P 〈 0.05 ）, while the intestinal pathogenic bacteria （Escherichia coli, Enterococcus and Clostridium etc. ） was significantly reduced （P 〈 0.05 ）. Conclusion ： The EN therapy with additionalbifidobacteria can effectively improvethe intestinal flora of patients with severe stroke, and promote the rehabilitation of patients.