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卵巢癌组织中VEGF及MVD的表达及临床意义 被引量：1

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摘要 目的分析微血管密度(MVD)以及卵巢上皮性肿瘤血管内皮生长因子(VEGF)的表达情况,分析两者与临床病理的关系。方法选取卵巢上皮性肿瘤标本88例和正常卵巢组织标本35例,采用免疫组化染色方法检测所有标本中VEGF及MVD的表达情况,分析两者相关性及与卵巢上皮性肿瘤患者临床病理因素之间的关系。结果 VEGF在卵巢癌组织中的表达阳性率为92.00%,MVD平均值为30.26±8.69,显著高于良性卵巢上皮性肿瘤组织VEGF的阳性表达率及MVD平均值(P<0.05);而良性卵巢上皮性肿瘤组织VEGF的阳性表达率及MVD平均值均高于正常对照组(P<0.05)。VEGF阳性表达的卵巢癌组织中MVD平均值显著高于VEGF阴性表达者,VEGF阳性表达与MVD平均值呈正相关(P<0.05)。卵巢癌组织中VEGF阳性表达与肿瘤的临床分期及细胞分化程度存在明显相关性(P<0.05),而与卵巢癌的肿瘤直径、组织学类型以及年龄无明显关系(P>0.05)。MVD与肿瘤的临床病理特征无明显的相关性(P>0.05)。结论 VEGF及MVD均能反映卵巢上皮性肿瘤的良恶性和恶性进展程度,并可能成为卵巢癌临床生物学治疗的参考指标。
作者 韩翠香
机构地区 神木县医院妇产科
出处 《中国妇幼保健》 CAS 2016年第18期3838-3840,共3页 Maternal and Child Health Care of China
关键词 卵巢上皮性肿瘤 血管内皮生长因子 微血管密度
分类号 R737.31 [医药卫生—肿瘤]
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参考文献9

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中国妇幼保健
2016年 第18期

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