CK7、P63乳腺硬化性腺病与乳腺癌中的临床病理分析

Clinicopathological analysis on CK7 and P63 in sclerosing adenosis of the breast and breast cancer

目的探讨CK7、P63乳腺硬化性腺病与乳腺癌中的临床病理分析。方法选取该院2014年1月-2015年1月收治的60例乳腺癌及40例乳腺硬化性腺病患者的病理学标本为研究对象,对其进行免疫组化检测,分析CK7、P63的阳性表达情况。结果 CK7呈颗粒状表达于腺上皮的胞浆中,CK7在乳腺硬化性腺病的表达高于乳腺癌,差异有统计学意义(P<0.05)。P63主要表达于导管周围的肌上皮,P63在乳腺硬化性腺病的表达高于乳腺癌,差异有统计学意义(P<0.05)。结论 CK7、P63能够客观地显示出乳腺腺泡和导管的基本结构,在乳腺硬化性疾病的表达加强,恶性肿瘤较弱,可用于乳腺硬化性腺病与乳腺癌的鉴别诊断。

Objective To conduct clinicopathological analysis on CK7 and P63 in sclerosing adenosis of the breast and breast cancer. Methods The pathological specimens of 60 patients with breast cancer and 40 patients with sclerosing adenosis of the breast were selected from the hospital from January 2014 to January 2015, immunohistochemical staining was carried out to analyze the positive expressions of CK7 and P63. Results Granular CK7 expressed in cytoplasm of glandular epithelium, the expression of CK7 in sclerosing adenosis of the breast was statistically significantly higher than that in breast cancer （P〈0. 05 ） . P63 mainly expressed in myoepithelial around catheter, the ex- pression of P63 in sclerosing adenosis of the breast was statistically significantly higher than that in breast cancer （P 〈 0. 05 ） . Conclusion CK7 and P63 can objectively show the basic structure of acini and ducts of mammary gland, the expressions of CK7 and P63 are high in sclerosing adenosis of the breast and low in malignant tumor, which can be used for differential diagnosis of sclerosing adenosis of the breast and breast cancer.